Sökning: "CYP2D6"

Visar resultat 1 - 5 av 45 avhandlingar innehållade ordet CYP2D6.

  1. 1. Pharmacogenetic analysis in sickness and in health - for better or for worse

    Författare :Mia Wadelius; Uppsala universitet; []
    Nyckelord :Medical sciences; Pharmacogenetics; NAT2; CYP2D6; CYP2C19; CYP17; GSTP1; sulphasalazine; agranulocytosis; prostate cancer; pregnancy; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : An individual's pharmacogenetic constitution may predict response to drugs, hormones and toxins, and might be a susceptibility factor for disease. Pharmacogenetic diversity is especially pronounced for drug metabolising enzymes. LÄS MER

  3. 2. Clinical Aspects of Depression in Psychiatric Care

    Författare :Marie Asp; Lund Psykiatri; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; depression; suicidality; psychiatric comorbidity; personality disorders; anxiety disorders; Coping strategies; pharmacogenetics; CYP2D6;

    Sammanfattning : .... LÄS MER

  4. 3. Migraine in women : Epidemiological, clinical, genetic, and experimental aspects

    Författare :Peter Mattsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Migraine; aura; prevalence; age; CYP2D6; GSTM1; cold induced headache; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Migraine is a significant public-health problem. Few studies have focused on migraine inmiddle-aged and older women in the general population. LÄS MER

  5. 4. First-pass Intestinal Metabolism of Drugs : Experiences from in vitro, in vivo and simulation studies

    Författare :Helena Anna Thörn; Hans Lennernäs; Paul Alfred Dickinson; Brian Houston; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; metabolism; CYP3A4; CYP2C9; CYP2D6; UGT; glucuronidation; physiologically based pharmacokinetic model; modelling; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. LÄS MER

  7. 5. Pharmacogenetics from a Forensic Perspective : CYP2D6 and CYP2C19 genotype distributions in autopsy cases

    Författare :Anna-Lena Zackrisson; Johan Ahlner; Bertil Lindblom; Magnus Ingelman-Sundberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : In Sweden about 550 individuals die every year due to drug intoxication. A challenge for the forensic toxicologist is to determine whether or not the analytical results can explain intoxication as a cause of death. The most common drugs found among intoxication cases are psychiatric drugs and analgesics. LÄS MER