Sökning: "CYP2D6"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet CYP2D6.

  1. 1. Pharmacogenetic analysis in sickness and in health - for better or for worse

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mia Wadelius; Uppsala universitet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; Pharmacogenetics; NAT2; CYP2D6; CYP2C19; CYP17; GSTP1; sulphasalazine; agranulocytosis; prostate cancer; pregnancy; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : An individual's pharmacogenetic constitution may predict response to drugs, hormones and toxins, and might be a susceptibility factor for disease. Pharmacogenetic diversity is especially pronounced for drug metabolising enzymes. LÄS MER

  2. 2. Migraine in women : Epidemiological, clinical, genetic, and experimental aspects

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Peter Mattsson; Uppsala universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Migraine; aura; prevalence; age; CYP2D6; GSTM1; cold induced headache; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi; Neurology; neurologi;

    Sammanfattning : Migraine is a significant public-health problem. Few studies have focused on migraine inmiddle-aged and older women in the general population. LÄS MER

  3. 3. First-pass Intestinal Metabolism of Drugs Experiences from in vitro, in vivo and simulation studies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Helena Anna Thörn; Uppsala universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; metabolism; CYP3A4; CYP2C9; CYP2D6; UGT; glucuronidation; physiologically based pharmacokinetic model; modelling; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. LÄS MER

  4. 4. Pharmacogenetics from a Forensic Perspective CYP2D6 and CYP2C19 genotype distributions in autopsy cases

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Anna-Lena Zackrisson; Johan Ahlner; Bertil Lindblom; Magnus Ingelman-Sundberg; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : In Sweden about 550 individuals die every year due to drug intoxication. A challenge for the forensic toxicologist is to determine whether or not the analytical results can explain intoxication as a cause of death. The most common drugs found among intoxication cases are psychiatric drugs and analgesics. LÄS MER

  5. 5. Pharmacokinetic consequences of CYP2D6 genotypes with emphasis on gene duplication/amplification

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Sciences and Technology

    Författare :Per Dalén; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug metabolism; CYP2D6. debrisoquine; nortriptyline; quinidine; genotype; phenotype; cytochrome P450; gene duplication; gene amplification;

    Sammanfattning : The relationship between the major Caucasian and Oriental CYP2D6 genotypes and the disposition of two CYP2D6 substrates nortriptyline and debrisoquine was investigated. Caucasians with 0, 1, 2, 3/4 and 13 functional CYP2D6-genes as well as Chinese and Korean subjects homo- and heterozygous for the CYP2D6*1 and CYP2D6*10 alleles were included. LÄS MER