Sökning: "Tyrosine kinase inhibition"

Visar resultat 1 - 5 av 119 avhandlingar innehållade orden Tyrosine kinase inhibition.

1. 1. Pharmaceutical Protection of Beta-Cells in Diabetes : Using Tyrosine Kinase Inhibition and NOX4 Inhibitors

   Författare :Andris Elksnis; Per-Ola Carlsson; Nils Welsh; Sergiu-Bogdan Catrina; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes mellitus; Tyrosine kinase inhibitors; Imatinib; AMPK; Oxidative stress; NADPH-oxidase; NOX; NOX4; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Diabetes mellitus is a complex and heterogenous disease, with loss of beta-cell function and mass being a characteristic of not only type 1 diabetes (T1D), but also type 2 diabetes (T2D). In T1D, inappropriate inflammatory signaling is thought to participate in the autoimmune suppression and destruction of beta-cells. LÄS MER

3. 2. Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2

   Författare :Inga Dikic; Olli Silvennoinen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Protein phosphorylation; tyrosine kinase; Pyk2 FAK; neuronal differentiation; Ras MAP kinase pathway; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : The proline-rich tyrosine kinase (Pyk2) together with focal adhesion kinase (FAK) define a family of non-receptor protein tyrosine kinases that are regulated by diverse stimuli. Activation of Pyk2 has been implicated in multiple signaling events, including modulation of ion channels, activation of MAP kinase cascades and apoptotic cell death. LÄS MER

4. 3. Using Light to Regulate the Activity of RET Kinase: Design, synthesis and evaluation of photoswitchable DFG-out RET kinase inhibitors

   Författare :Yongjin Xu; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RET kinase; kinase inhibitor; DFG-out; photoparmacology; azoheteroarene; Buchwald-Hartwig coupling; quinoline; 7-azaindole;

   Sammanfattning : Protein kinases are essential for signal transduction and regulate most cellular processes, such as metabolism, membrane transport, motility, and cell cycle. Although they play a critical role in cells and have a strong association with diseases, details of their physiologic and pathologic mechanisms remain at least partially unclear, especially the spatiotemporal dynamics of the signalling. LÄS MER

5. 4. Aspects on long-term treatment with tyrosine kinase inhibitors in Chronic myeloid leukemia

   Författare :Sofia Jönsson; Göteborgs universitet; []
   Nyckelord :Chronic myeloid leukemia; tyrosine kinase inhibitor; imatinib; molecular response; adherence; mesechymal stem cells; osteoblast differentiation; dasatinib;

   Sammanfattning : Chronic myeloid leukemia (CML) is caused by the tyrosine kinase activity of the oncoprotein BCR-ABL. The introduction of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has profoundly changed the prognosis of CML. Currently, there are three TKIs approved for treatment of CML, imatinib, nilotinib and dasatinib. LÄS MER

7. 5. Inhibition of PDGF receptor signaling in tumor stroma : Effects on interstitial hypertension, drug uptake and therapeutic response

   Författare :Kristian Pietras; Sven Påhlman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; PDGF; tumor; stroma; tyrosine kinase inhibitor; combination therapy; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : The role of platelet-derived growth factor (PDGF) in malignancies involves both autocrine and paracrine stimulation of cells within the tumor. The interstitial fluid pressure (IFP) is one of the forces that govern the transvascular flow of fluids. LÄS MER