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Visar resultat 16 - 20 av 53 avhandlingar som matchar ovanstående sökkriterier.

  1. 16. Design and Synthesis of Inhibitors Targeting BACE-1, an Aspartic Protease Involved in the Pathogenesis of Alzheimer’s Disease

    Författare :Veronica Sandgren; Ingemar Kvarnström; Bertil Samuelsson; Thomas Olsson; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia, occurring in an estimated 24 million people worldwide. Accumulation of amyloid-b peptides leads to development of plaques in the brain, which eventually stimulates hyperphosphorylation of tau proteins leading to tangles. This is believed to play a crucial role in the pathology of AD. LÄS MER

  3. 17. Elucidating Genetic and Biochemical Aspects of the P1 and Sda Carbohydrate Histo-Blood Group Antigens

    Författare :Linn Stenfelt; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood Group; P1 antigen; Sda antigen; A4GALT; B3GALNT2; glycosyltransferase; red blood cell; transfusion medicine;

    Sammanfattning : Human histo-blood groups are inherited polymorphic variants that occur in the molecular structures on the humanred blood cell (RBC) surface. Introducing foreign RBCs into a recipient lacking an antigen may activate the humoraldefence leading to a hemolytic transfusion reaction. LÄS MER

  4. 18. Lateralization of human olfaction : cognitive functions and electrophysiology

    Författare :Daniel Broman; Steven Nordin; Matthias Laska; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Human olfaction; Laterality; Olfactory processes; Odor familiarity; Odor identification; OERP; Psychology; Psykologi;

    Sammanfattning : In this thesis lateralization of olfactory functions was investigated by both behavioral and electrophysiological assessment, the latter with the olfactory event-related potential (OERP) technique. The olfactory sense is primarily ipsilateral in that a stimulus that is presented to one nostril is initially processed in the same hemisphere. LÄS MER

  5. 19. Visual evoked potentials in the horse

    Författare :Lena Ström; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Vision is an important sense for horses, both for survival in the wild and when horses are used for work, sport or recreation. However, it is often difficult to diagnose visual impairment in this species. LÄS MER

  7. 20. Tools and annotations for variation

    Författare :Gerard C.P. Schaafsma; Proteinbioinformatik; []
    Nyckelord :Annotation; genetic variation; benchmarks; databases; disease groups; pathogenicity; proteins; representativeness; sensitivity; variant effect analysis;

    Sammanfattning : Since the finishing of the Human Genome Project, many next-generation (NGS) or high-throughput sequencing platforms have emerged. One of the applications of NGS technology, variant discovery, can serve as a basis for precision medicine. LÄS MER