Sökning: "Bertil Samuelsson"

Hittade 5 avhandlingar innehållade orden Bertil Samuelsson.

1. 1. Synthesis and chemical modification of some carbohydrates

   Författare :Bertil Samuelsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : .... LÄS MER

3. 2. Design and Synthesis of Inhibitors Targeting the Aspartic Proteases HIV-1 PR and BACE-1

   Författare :Jenny Adrian Meredith; Bertil Samuelsson; Ulf Ellervik; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis describes the synthesis of molecules designed for inhibition of two aspartic proteases, viral HIV-1 PR and human BACE-1. It also reports on the structure activity relationships of the targeted enzyme inhibitors. It is estimated that currently 33 million people are infected with HIV, the causative agent of AIDS. LÄS MER

4. 3. Design and Synthesis of Amine Building Blocks and Protease Inhibitors

   Författare :Susana Ayesa Alvarez; Bertil Samuelsson; Thomas Olsson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

   Sammanfattning : The first part of this thesis addresses the design and synthesis of amine building blocks accomplished by applying two different synthetic procedures, both of which were developed using solid-phase chemistry. Chapter 1 presents the first of these methods, entailing a practical solid-phase parallel synthesis route to N-monoalkylated aminopiperidines and aminopyrrolidines achieved by selective reductive alkylation of primary and/or secondary amines. LÄS MER

5. 4. Design and Synthesis of BACE-1 Inhibitors : Novel Compounds Targeting an Aspartic Protease Important in the Pathogenesis of Alzheimer’s Disease

   Författare :Catarina Björklund; Bertil Samuelsson; Rolf Johansson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis deals with the design and synthesis of protease inhibitors targeting the aspartic protease BACE-1 (β-site APP cleaving enzyme-1), an enzyme important in the pathogenesis of Alzheimer’s disease. The inhibitors are evaluated with respect to inhibition data, in a structure-activity relationship part. LÄS MER

7. 5. Design and Synthesis of Inhibitors Targeting BACE-1, an Aspartic Protease Involved in the Pathogenesis of Alzheimer’s Disease

   Författare :Veronica Sandgren; Ingemar Kvarnström; Bertil Samuelsson; Thomas Olsson; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia, occurring in an estimated 24 million people worldwide. Accumulation of amyloid-b peptides leads to development of plaques in the brain, which eventually stimulates hyperphosphorylation of tau proteins leading to tangles. This is believed to play a crucial role in the pathology of AD. LÄS MER