Sökning: "P1 antigen"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden P1 antigen.
1. Elucidating Genetic and Biochemical Aspects of the P1 and Sda Carbohydrate Histo-Blood Group Antigens
Sammanfattning : Human histo-blood groups are inherited polymorphic variants that occur in the molecular structures on the humanred blood cell (RBC) surface. Introducing foreign RBCs into a recipient lacking an antigen may activate the humoraldefence leading to a hemolytic transfusion reaction. LÄS MER
2. Studies on the genetic basis of Pk, P and P1 blood group antigen expression
Sammanfattning : The clinically important carbohydrate P/GLOB blood group systems and collection give rise to both common (P1, P2) and rare (p, P1k, P2k) blood group phenotypes. The associated antibodies are implicated in severe transfusion reactions and recurrent spontaneous abortions. LÄS MER
3. Molecular genetics of human carbohydrate defined blood groups. Studies of the ABO and P blood group systems
Sammanfattning : The aim of this study was to explore the molecular genetics of the carbohydrate defined blood group ABO and P systems.The blood group ABO system is the clinically most significant system in transfusion medicine. Using modern molecular biology, a number of the ABO alleles have been characterized. LÄS MER
4. Genetics and Expression of Glycosphingolipids in the P1PK and GLOB Histo-Blood Group Systems
Sammanfattning : The glycosphingolipid (GSL) antigens in the clinically important P1PK and GLOB blood group systems are present on erythrocytes as well as other tissues and are so-called histo-blood group antigens. Blood group antigens of carbohydrate nature are products of enzymes, so-called glycosyltransferases, adding sugars in a step-wise manner to an acceptor substrate. LÄS MER
5. Studies on the Polymorphism and Transcriptional Regulation of the ABO and P1PK Histo-blood Group Genes
Sammanfattning : Antigens of the clinically important ABO and P1PK blood group systems are carbohydrate structures. Thus the underlying genes do not encode antigens directly but glycosyltransferases that add specific sugar molecules to selected precursor chains. LÄS MER