Sökning: "voltage-gated potassium channels"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden voltage-gated potassium channels.

  1. 1. Molecular aspects on voltage-sensor movement

    Detta är en avhandling från Institutionen för klinisk och experimentell medicin

    Författare :Amir Broomand; Linköpings universitet.; Linköpings universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Potassium channels; voltage-gated; chemistry; metabolism; physiology; patch-clamp techniques; oocytes; MEDICINE; MEDICIN;

    Sammanfattning : Voltage-gated ion channels are fundamental for electrical signaling in living cells. They are composed of four subunits, each holding six transmembrane helices, S1-S6. Each subunit contains a voltage-sensor domain, S1-S4, and a pore domain, S5-S6. LÄS MER

  2. 2. Dynamics of the voltage-sensor domain in voltage-gated ion channels Studies on helical content and hydrophobic barriers within voltage-sensor domains

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Christine S. Schwaiger; KTH.; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage-sensor; VSD; Kv1.2- 2.1; F233; hydrophobic barrier; alpha-helix; 3 10 -helix; NATURAL SCIENCES Physics Condensed matter physics Biological physics; NATURVETENSKAP Fysik Kondenserade materiens fysik Biologisk fysik;

    Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability and thus dysfunctional channels can cause disease. Understanding how the voltage-sensor of these channels activate and inactivate could potentially be useful in future drug design of compounds targeting neuronal excitability. LÄS MER

  3. 3. Site and Mechanism of Action of Resin Acids on Voltage-Gated Ion Channels

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Malin Silverå Ejneby; Linköpings universitet.; Linköpings universitet.; [2018]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Voltage-gated ion channels are pore-forming membrane proteins that open or close their gates when the voltage across the membrane is changed. They underlie the electrical activity that enables the heart to pump blood and the brain to receive and send signals. LÄS MER

  4. 4. Role of potassium channels in regulating neuronal activity

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Neuroscience

    Författare :Göran Klement; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Potassium channels; threshold dynamics; trafficking; hERG; SMOCs; excitability;

    Sammanfattning : The firing behaviour of excitable cells is fundamental for the information processing in multicellular organisms, varying from single spikes to different forms of repetitive firing. Of the many regulators, voltage gated potassium channels play a major role. In this thesis some aspects of the potassium channel regulation of firing are explored. LÄS MER

  5. 5. Conformational Changes during Potassium-Channel Gating

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Jakob Renhorn; Linköpings universitet.; Linköpings universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ion-channel; electrophysiology; neuron; Jonkanal; neurologi; elektrofysiologi; neuron; aktionspotential;

    Sammanfattning : Voltage-gated ion channels have a paramount importance in many physiological processes such as cell-to-cell communication, action potential-propagation, and cell motility. Voltage-gated ion channels are characterized by their ability to sense membrane voltage and to greatly change channel activity in response to small changes in the voltage. LÄS MER