Sökning: "Dose-response relationships"
Visar resultat 1 - 5 av 36 avhandlingar innehållade orden Dose-response relationships.
1. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response
Sammanfattning : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. LÄS MER
2. Transcriptional biomarkers of toxicity – powerful tools or random noise? : An applied perspective from studies on bivalves
Sammanfattning : Aquatic organisms are constantly at risk of being exposed to potentially harmful chemical compounds of natural or anthropogenic origin. Biological life can for instance respond to chemical stressors by changes in gene expression, and thus, certain gene transcripts can potentially function as biomarkers, i.e. LÄS MER
3. Cause-Specific Mortality and Physical Fitness in Mental Disorders - Epidemiological and Internventional Studies
Sammanfattning : Mental illnesses are common and constitute a substantial health-related and financial burden on both the individual and society. Mental disorders in general have increased risk of somatic morbidity. An early age of onset is commonly seen in anxiety disorders and the prevalence of these disorders has increased in youth in recent years. LÄS MER
4. Bone and kidney effects from cadmium exposure : dose effect and dose response relationships
Sammanfattning : Cadmium is a heavy metal that has been dispersed in the environment during the last century due to human activity. It is well known that high cadmium exposure causes renal damage and in severe cases also osteoporosis and osteomalacia. Osteoporosis is a major cause of morbidity worldwide. LÄS MER
5. Dose-response modeling : evaluation, application, and development of procedures for benchmark dose analysis in health risk assessment of chemical substances
Sammanfattning : In this thesis, dose-response modeling and procedures for benchmark dose (BMD) analysis in health risk assessment of chemical substances have been investigated. The BMD method has been proposed as an alternative to the NOAEL (no-observedadverse- effect-level) approach in health risk assessment of non-genotoxic agents. LÄS MER