Sökning: "viral culture"

Visar resultat 1 - 5 av 78 avhandlingar innehållade orden viral culture.

  1. 1. Interaction Characteristics of Viral Protease Targets and Inhibitors : Perspectives for drug discovery and development of model systems

    Författare :Cynthia F Shuman; Jordan J N Tang; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; viral proteases; biomolecular interactions; kinetics; thermodynamics; biosensors; drug discovery; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : Viral proteases are important targets for anti-viral drugs. Discovery of protease inhibitors as anti-viral drugs is aided by an understanding of the interactions between viral protease and inhibitors. This thesis addresses the characterization of protease-inhibitor interactions for application to drug discovery and model system development. LÄS MER

  3. 2. Viral infections in children with cancer

    Författare :Anna Lindblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Viral infections are the most common cause of infection morbidity in children. Nevertheless, few studies have been devoted to exploring the viral panorama in children receiving chemotherapy for cancer. LÄS MER

  4. 3. Genetic vaccination against acute viral disease

    Författare :Marina N Fleeton; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Semliki Forest virus; Alphavirus. Influenza A virus; DNA vaccines. Influenza vaccine. Respiratory Syncytial Viruses; Louping Ill. Flavivirus Infections;

    Sammanfattning : This thesis describes the development of recombinant vaccines based on the Semliki Forest virus (SFV) expression system. Immunisation of mice with recombinant virus particles, a layered DNA/RNA plasmid vector, and recombinant self-replicating RNA were carried out and the protective effect of these recombinant vaccines against viral challenge were examined. LÄS MER

  5. 4. Viral dUTPases, Recombinant Expression, Purification and Characterization

    Författare :Anna-Carin Bergman; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteins; nucleocapsid protein; retrovirus; herpesvirus; dUTPase; nucleotide metabolism; enzymology; Proteiner; enzymologi;

    Sammanfattning : The enzyme deoxyuridine 5’-triphosphate nucleotidohydrolase (dUTPase, EC 3.6.1.23) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate. LÄS MER

  7. 5. Exploring the diversity and evolution of giant viruses in deep sea sediments using genome-resolved metagenomics

    Författare :Disa Bäckström; Thijs J. G. Ettema; Anna J. Szekely; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metagenomics; binning; viruses; NCLDV; Megavirales; viral evolution.;

    Sammanfattning : Viruses are the most abundant biological entities on this planet, which is impressive considering that they are completely dependent on their hosts for reproduction. Recently the idea of what viruses are has changed dramatically, with the discovery of giant viruses that belong to the Nucleocytoplasmic Large DNA Viruses (NCLDV), such as Mimiviridae, Marseilleviridae, and the proposed families Pandoraviruses, and Pithoviruses. LÄS MER