Sökning: "type III secretion"

Visar resultat 41 - 45 av 177 avhandlingar innehållade orden type III secretion.

  1. 41. Non-coding RNAs in beta cell insulin secretion - emerging players in Type 2 Diabetes pathogenesis

    Författare :Jones Ofori; Diabetes - öcellsexocytos; []
    Nyckelord :T2D; insulin secretion; exocytosis; ncRNAs; GAS5; miR-152; miR-335; miR-130a b; miR-375; STXBP1; SNAP25; SYT13; PDHA1; PDX1; glucocortiocoid; beta cell function; glucose metabolism;

    Sammanfattning : Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will be affected by 2040. LÄS MER

  3. 42. Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation

    Författare :Caroline Miranda; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Glucagon; α-Cell; Optogenetics;

    Sammanfattning : ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and explored the spatio-temporal relationship between cell activation and glucagon release. LÄS MER

  4. 43. The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes

    Författare :Tina Rönn; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; oxidative phosphorylation; GWAS; SNP; DNA methylation; epigenetics; type 2 diabetes;

    Sammanfattning : The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. LÄS MER

  5. 44. Anti-diabetic and anti-inflammatory effects of medicinal plants in a type 2 diabetic animal model

    Författare :Ezarul Faradianna Lokman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 diabetes;

    Sammanfattning : Medicinal plants have been suggested since ancient times to be a good source of drugs for treating diabetes. The aims of this thesis were to identify the anti-diabetic effects and to understand further the mechanisms involved for two traditional plants, borapetol B (C1) isolated from Tinospora crispa, and Gynostemma pentaphyllum (GP), in diabetic rats. LÄS MER

  7. 45. Towards novel antibacterials : Synthesis and identification of natural product inspired inhibitors of Chlamydia trachomatis and development of chemical probes targeting virulence of Pseudomonas aeruginosa

    Författare :Michael Saleeb; Mikael Elofsson; Anna Linusson Jonsson; Andreas Kirschning; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibacterials; antibiotics; small molecules; natural products; benzofuran; dihydrobenzofuran; the type III secretion system; Pseudomonas aeruginosa; Chlamydia trachomatis; phenotypic screening; high-throughput screening; surface plasmon resonance; drug discovery; bacterial toxins; enzyme inhibitors; organisk kemi; Organic Chemistry;

    Sammanfattning : Antibiotic resistance has evolved significantly to become one of the serious threats to public health today. Yet, the pipeline of new antibiotics is drying up and is lagging behind the challenging needs. LÄS MER