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  1. 1. Chemical attenuation of bacterial virulence : small molecule inhibitors of type III secretion

    Författare :Anna Kauppi; Mikael Elofsson; Anders Karlén; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; Organic chemistry; Organisk kemi;

    Sammanfattning : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. LÄS MER

  3. 2. Coordinating type III secretion system biogenesis in Yersinia pseudotuberculosis

    Författare :Jyoti Mohan Gurung; Matthew S Francis; Maria Fällman; Dirk Linke; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yersinia pseudotuberculosis; type III secretion system; YscX; YscY; YopN; TyeA; secretion signal; N-terminal region; site-directed mutagenesis; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

    Sammanfattning : Various Gram-negative bacteria utilize type III secretion system (T3SS) to deliver effectors into eukaryotic host cells and establish mutualistic or pathogenic interactions. An example is the Ysc-Yop T3SS of pathogenic Yersinia species. LÄS MER

  4. 3. Type III Secretion Mediated Translocation of Effector Exoenzymes by Pseudomonas aeruginosa

    Författare :Charlotta Sundin; Åke Forsberg; Anthony Pugsley; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Pseudomonas aeruginosa; type III secretion system; ExoS; ExoT; PcrV; PcrG; PopB; PopD; PopN; type IV pili; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : .... LÄS MER

  5. 4. Virulence mechanisms of pathogenic Yersinia : aspects of type III secretion and twin arginine translocation

    Författare :Moa Lavander; Åke Forsberg; George Salmond; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Yersinia pestis; Yersinia pseudotuberculosis; bacterial pathogenesis; type III secretion; twin arginine translocation; virulence mechanisms; YscU; YscP; YscF; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The pathogenic bacteria Yersinia pestis and Y. pseudotuberculosis are related to the degree where the former is considered a subspecies of the latter, and still they cause disease of little resemblance in humans. Y. pestis is the causative agent of lethal bubonic and pneumonic plague, while Y. LÄS MER

  7. 5. Multiple functions of YopN in the Yersinia pseudotuberculosis type III secretion system : from regulation to in vivo infection

    Författare :Sarp Bamyaci; Åke Forsberg; Edouard Galyov; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system; Yersinia; YopN; virulence; phagocytosis; mouse infection; secretion kinetics;

    Sammanfattning : The type 3 secretion systems (T3SSs) are virulence mechanisms used by various Gram-negative bacteria to overcome the host immunity. They are often target-cell contact induced and activated. Activation results in targeting of virulence effector substrates into host cells. LÄS MER