Sökning: "positive selection"

Visar resultat 1 - 5 av 345 avhandlingar innehållade orden positive selection.

  1. 1. Robust inference of gene regulatory networks : System properties, variable selection, subnetworks, and design of experiments

    Författare :Torbjörn E. M. Nordling; Elling W Jacobsen; Rolf Findeisen; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; network inference; reverse engineering; variable selection; model selection; feature selection; subset selection; system identification; system theory; network theory; subnetworks; design of experiments; perturbation experiments; gene regulatory networks; biological networks;

    Sammanfattning : In this thesis, inference of biological networks from in vivo data generated by perturbation experiments is considered, i.e. deduction of causal interactions that exist among the observed variables. Knowledge of such regulatory influences is essential in biology. LÄS MER

  3. 2. Pathogen-mediated selection in the immune system of rodents : Exploring selection targets, functional effects and trade-offs

    Författare :Mridula Nandakumar; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pathogen-mediated selection; bank voles; Myodes glareolus; immune system; balancing selection; immune response; rodents; positive selection; transcriptomics;

    Sammanfattning : Pathogens cause disease and play an important role in shaping evolution of the host immune system. They create pressure on host immunity to evolve in numerous ways, most commonly by increasing divergence between species (positive selection) or increasing polymorphisms within a population (balancing selection). LÄS MER

  4. 3. Tracing selection and adaptation along an environmental gradient in Populus tremula

    Författare :David Hall; Pär Ingvarsson; Thomas Bataillon; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Local adaptation; Selection; genetic differentiation; QST; FST; Association study; frequency spectra; recurrent hitchhiking; selective sweep; Tree; Populus; natural selection; quantitative genetics; Terrestrial ecology; Terrestrisk ekologi; Population Biology; populationsbiologi; genetik; Genetics;

    Sammanfattning : The distribution of the expressed genotype is moved around in the population over time byevolution. Natural selection is one of the forces that act on the phenotype to change the patterns ofnucleotide variation underlying those distributions. LÄS MER

  5. 4. Detecting Signatures of Selection within the Dog Genome

    Författare :Abhirami Ratnakumar; Matthew Webster; Kerstin Lindblad-Toh; Greg Barsh; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; dog; evolution; domestication; PRDM9; recombination; positive selection; selective sweep;

    Sammanfattning : Deciphering the genetic basis of phenotypic diversity is one of the central aims of biological research. Domestic animals provide a unique opportunity for making substantial progress towards this goal. LÄS MER

  7. 5. Criterion-referenced measurement for educational evaluation and selection

    Författare :Christina Wikström; Widar Henriksson; Roger Murphy; Umeå universitet; []
    Nyckelord :Assessment; Competition; Criterion-referenced; Education; Evaluation; Grading; Grade inflation; Measurement; Selection; Validity; Beteendevetenskapliga mätningar; pedagogik; Education;

    Sammanfattning : In recent years, Sweden has adopted a criterion-referenced grading system, where the grade outcome is used for several purposes, but foremost for educational evaluation on student- and school levels as well as for selection to higher education. This thesis investigates the consequences of using criterion-referenced measurement for both educational evaluation and selection purposes. LÄS MER