Sökning: "steroid therapy"

Visar resultat 11 - 15 av 61 avhandlingar innehållade orden steroid therapy.

1. 11. Sex steroid effects on normal breast tissue

   Författare :Gunnar Söderqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Estrogen receptor; progesterone receptor; proliferation; breast epithelialcells; mammary epithelium; sulfatase; 17 HSD; regional differences; sex steroids;

   Sammanfattning : In Sweden, it is estimated that about one million women are treated with estrogen/progestogen for contraception and hormone replacement therapy (HRT). The possibility of an increased cancer risk in target organs has been vividly discussed for many years. LÄS MER

3. 12. Exploring vitamin D and steroid hormone receptors – from healthy elderly to prostate cancer cells

   Författare :Maria Araceli Diaz Cruz; Maria Faresjö; Dennis Larsson Dennis Larsson; Johan Staaf; Jönköping University; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; vitamin D; steroid hormone receptors; lifestyle; methylation; SNPs; healthy elderly; prostate cancer cells; crosstalk; PDIA3;

   Sammanfattning : The genetic background together with environmental factors and lifestyle are key contributors to the health of an individual. Genetic background is inherited and irreversible unless mutations occur. However, lifestyle habits (i.e. LÄS MER

4. 13. Sex steroid hormone receptors : inner ear and hearing

   Författare :Rusana Simonoska; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : It is well known that hearing loss is more profound in elderly males than females, regardless of noise exposure. Also, an age-related hearing decline starts much earlier in males, already after the age of 30, while in women, the decline does not start until the age of 50. LÄS MER

5. 14. Hormone therapy and the breast : aspects on proliferation, apoptosis and mammographic density

   Författare :Peter Conner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Breast cell proliferation; fine needle aspiration cytology; menopause; hormone replacement therapy; tibolone; mammographic breast density; continuous combined hormone therapy; p53; apoptosis; cynomolgus macaques.;

   Sammanfattning : Breast cancer is the major malignancy among women in the western world. The breast is clearly a target organ for sex steroid hormones and hormonal treatments have been associated with an increased risk of breast cancer. Still, basic knowledge as to how sex steroids influence the normal breast is remarkably poor. LÄS MER

7. 15. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

   Författare :Vendela Asp; Ingvar Brandt; Ulrika Bergström; Olle Söder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; Toxicology; Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

   Sammanfattning : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. LÄS MER