Sökning: "sulfatase"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet sulfatase.

  1. 1. Strategies to improve and balance the expression levels of recombinant proteins in mammalian cell lines

    Författare :Mona Moradi Barzadd; Johan Rockberg; Alan Dickson; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CHO; HEK293; Aggregation; Bispecific; Cancer assay; Cell line engineering; sulfatase; biologics; transcriptomic; Biotechnology; Bioteknologi;

    Sammanfattning : Proteins are the building blocks of all living organisms enabling us to function and survive. There are more than 100,000 different proteins in the human body performing a variety of vital tasks. LÄS MER

  2. 2. Molecular investigation of mucopolysaccharidosis type II (Hunter syndrome) in man

    Författare :Stanislav L. Karsten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mucopolysaccharidosis type II; Hunter syndrome; MPSII; iduronate-2-sulfatase; mutational analysis; homologous nonhomologous recombination; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Mucopolysaccharidosis type II or Hunter syndrome is a rare lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2-sulfatase (IDS). The disorder is inherited in an X-linked recessive fashion and has a broad spectrum of clinical phenotypes ranging from severe to mild. LÄS MER

  3. 3. Development of chemical biology tools for metabolomics analysis : Phase II modifications as a link between host and microbiota co-metabolism

    Författare :Mario S. P. Correia; Daniel Globisch; Warwick Dunn; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; Chemical biology; sulfatase; Glucuronides; Phase II modifications; Microbiome; co-metabolism; method development; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Biomarker discovery is an extremely important field for early disease detection. New selective molecular markers are in high demand, as an earlier disease detection can lead to improved patient care. LÄS MER

  4. 4. Sex steroid effects on normal breast tissue

    Författare :Gunnar Söderqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen receptor; progesterone receptor; proliferation; breast epithelialcells; mammary epithelium; sulfatase; 17 HSD; regional differences; sex steroids;

    Sammanfattning : In Sweden, it is estimated that about one million women are treated with estrogen/progestogen for contraception and hormone replacement therapy (HRT). The possibility of an increased cancer risk in target organs has been vividly discussed for many years. LÄS MER

  5. 5. Studies of carbohydrate structure, properties and interactions by nmr spectroscopy

    Författare :Eric Morssing Vilén; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In this thesis the structure, properties and interactions of different types of carbohydrates were investigated by NMR spectroscopy. The structures of kappa- (κ) and kappa/mu- (κ/μ) carrageenan oligosaccharides were analyzed by studying the hydroxy protons. LÄS MER