Sökning: "spleen development"

Visar resultat 21 - 25 av 93 avhandlingar innehållade orden spleen development.

  1. 21. Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases

    Författare :Anton Sendel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, autoimmunity, and cancer. The cytoskeleton is essential for several important immune cell functions, including proliferation, movement, signaling, and vesicle trafficking. LÄS MER

  3. 22. Immunoregulation in an experimental model of allergic asthma

    Författare :Magnus Korsgren; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allergic asthma; macrophage migration inhibitory factor; eosinophils; gd T cells; NK1.1 T cells; natural killer cells; immunoglobulins; B cells; innate immunity; allergic airway inflammation; immediate hypersensitivity; Physiology; Fysiologi; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : In allergic asthma the immune response to antigen is inappropriate, leading to an inflammatory process in the respiratory mucosa. To further elucidate immunological mechanisms involved in the development of such inflammation, control mice and mice deficient in selected cell types or proteins, were used in experimental models of allergic asthma and anaphylaxis. LÄS MER

  4. 23. The impact of Staphylococcus aureus surface proteins on virulence

    Författare :Niklas Palmqvist; Göteborgs universitet; []
    Nyckelord :Staphylococcus aureus; septic arthritis; sepsis; virulence; cell wall-anchored proteins; surface proteins; fibrinogen.;

    Sammanfattning : Staphylococcus aureus is an important pathogen in humans with the potential to cause life-threatening invasive infections, including sepsis and septic arthritis. The pathogenicity of S. aureus depends on the expression of a variety of virulence factors. LÄS MER

  5. 24. Estrogen and raloxifene in experimental arthritis and osteoporosis

    Författare :Caroline Jochems; Göteborgs universitet; []
    Nyckelord :rheumatoid arthritis; osteoporosis; estrogen; raloxifene; mice;

    Sammanfattning : ABSTRACT In postmenopausal rheumatoid arthritis (RA), both the estrogen deficiency and the inflammatory disease contribute to the development of generalized osteoporosis. This leads to an increased risk of fracture, with high morbidity and mortality. More than 50% of women with postmenopausal RA suffer from osteoporosis. LÄS MER

  7. 25. Effect of quinoline-3-carboxamides on myeloid cells in inflammation and cancer

    Författare :Adnan Deronic; Immunologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quinoline-3-carboxamide; myeloid cell; inflammation; cancer; peritonitis; mammary carcinoma; fibrosis;

    Sammanfattning : The quinoline-3-carboxamides (Q compounds) are a family of small molecules that ameliorate various types of murine inflammatory autoimmune disease. One such compound has also demonstrated anti-tumor effects in murine tumor models. LÄS MER