Sökning: "short stem"

Visar resultat 1 - 5 av 114 avhandlingar innehållade orden short stem.

  1. 1. Potential Hazards for Haematopoietic Stem Cell Donors

    Författare :Simon Pahnke; Hans Hägglund; Gunnar Larfors; Nina Worel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell donor; stem cell transplantation; cancer; haematology; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The aim of this thesis has been to increase our knowledge about the allogeneic stem cell donation procedure and the associated risks for stem cell donors.  In a first study (paper I), we described the donation procedure and short-term side effects of 1957 donors included in the Nordic Register of Haematopoietic Stem Cell Donors. LÄS MER

  3. 2. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

    Författare :Måns Jergil; Lennart Dencker; Aldert Piersma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. LÄS MER

  4. 3. Defining Regulators of Human Hematopoietic Stem Cells

    Författare :Christine Karlsson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-throughput screening; Expansion; Hematopoietic stem cell; Cord blood; RNA interference; extrinsic Signaling molecules;

    Sammanfattning : Bone marrow transplantation (BMT) is a conceptual and elegant example of stem cell therapy, rendered possible by the dual capacity of hematopoietic stem cells (HSCs) to self-renew and differentiate. These defining features ultimately ensure the production of all blood cell lineages and simultaneous maintenance of the stem cell pool, thereby maintaining lifelong homeostasis. LÄS MER

  5. 4. Cellular and Molecular Pathways Governing Hematopoietic Stem Cell Fate

    Författare :Liping Yang; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell; hematopoiesis; bone marrow transplantation; lineage commitment; cytokine; Medicine human and vertebrates ; Clinical genetics; Klinisk genetik; extracellulära vätskor; Hematologi; Medicin människa och djur ; extracellular fluids; Haematology;

    Sammanfattning : Hematopoietic Stem Cells (HSCs) have been defined to have abilities of both self-renewal and multi-lineage differen-tiation. The balance between these abilities is rigorously controlled under steady-state status (homeostasis) and when the normal processes of self-renewal and differentiation become deregulated, a disorder of blood system (such as leukemias) can occur. LÄS MER

  7. 5. On New Implants - The results of five prospective, randomized RSA trials with aspects on phased introduction and continuous migration

    Författare :Mats Molt; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; New total knee arthroplasty; TKA; RSA; randomized; prospective; prediction; continuously migrating; safety; stability CR; PS; PF; PA; short stem; tourniquet;

    Sammanfattning : A concern that arises with any change in design or operative technique is whether it affects the long-term implant stability or not. One way to address this is, by measuring early micromotion, to predict the future revision rate. LÄS MER