Sökning: "extrinsic Signaling molecules"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden extrinsic Signaling molecules.

  1. 1. Defining Regulators of Human Hematopoietic Stem Cells

    Författare :Christine Karlsson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-throughput screening; Expansion; Hematopoietic stem cell; Cord blood; RNA interference; extrinsic Signaling molecules;

    Sammanfattning : Bone marrow transplantation (BMT) is a conceptual and elegant example of stem cell therapy, rendered possible by the dual capacity of hematopoietic stem cells (HSCs) to self-renew and differentiate. These defining features ultimately ensure the production of all blood cell lineages and simultaneous maintenance of the stem cell pool, thereby maintaining lifelong homeostasis. LÄS MER

  3. 2. Intrinsic and extrinsic mechanisms for B-cell lymphoma development and progression studied by global gene expression profiling

    Författare :Gustav Arvidsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mantle cell lymphoma (MCL) is a rare hematopoietic malignancy characterized by frequent relapses and poor survival, partly due to minimal residual disease, whereby a subset of malignant cells, harbored in protective niches, survive treatment. In vitro and ex vivo experiments have shown that MCL cells can be rescued from apoptosis through interactions with non- malignant cells such as stromal cells. LÄS MER

  4. 3. Interleukin 15 throughout murine natural killer cell biology

    Författare :Thuy Thanh Luu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are innate immune cells that mount responses against virally infected, transformed and allogeneic transplanted cells. Equipped with cytolytic molecules and death receptors, NK cells mediate cytotoxicity against cells expressing low levels of MHC class I (MHC-I) or high levels of stress-induced molecules. LÄS MER

  5. 4. Bone marrow mesenchymal stem and progenitor cells in myeloid malignancies

    Författare :Pingnan Xiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hematopoietic stem cells (HSCs) reside in bone marrow (BM) microenvironment / niche to self-renew and generate all types of mature blood cells in postnatal life. This process is called hematopoiesis. Normal hematopoiesis is tightly regulated by both intrinsic signaling in HSCs and extrinsic signals from BM niche. LÄS MER

  7. 5. The Role of Lhx2 During Organogenesis : - Analysis of the Hepatic, Hematopoietic and Olfactory Systems

    Författare :Åsa Kolterud; Leif Carlsson; Stefan Thor; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; LIM-homeobox gene; Lhx2; fetal liver; hepatic stellate cells; hematopoietic stem cells; septum transversum; self-renewal; odorant receptor genes; olfactory epithelium; olfactory sensory neuron; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : During embryonic development a variety of tissues and organs such as the lung, eye, and kidney are being formed. The generation of functional organs is regulated by reciprocal cell-cell interactions. Via the secretion of soluble molecules one type of cells affect the fate of their neighboring cells. LÄS MER