Sökning: "scrapie"
Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet scrapie.
1. Molecular changes in scrapie-infected neuroblastoma cells
Sammanfattning : .... LÄS MER
2. Prion-infection and Cellular Signaling : Influence of scrapie-infection on lipid raft-associated proteins
Sammanfattning : Prion diseases are a group of fatal neurodegenerative diseases affecting almost all mammals including humans. The diseases are caused by formation of the misfolded isoform of the cellular prion protein (PrPC) to the disease causing PrPSc. LÄS MER
3. Altered cell signaling linked to neurodegeneration : Studies on scrapie-infected neuroblastoma cells and activated microglia
Sammanfattning : Prion diseases are neurodegenerative disorders that can affect humans and animals. The underlying event is a conformational change of the normal cellular prion protein (PrPC) into an aberrant isoform termed PrP-scrapie (PrPSc). PrPSc is thought to lead to neurodegeneration and activation of glial cells. LÄS MER
4. Interactions of Prion Proteins and PrP-derived Peptides in Scrapie infection
Sammanfattning : Prion diseases are fatal and incurable spongiform encephalopathies that occur amongst mammals. The central pathological event is the misfolding of the cellular prion protein (PrPC) into an amyloid, neurotoxic isoform called scrapie (PrPSc). PrPSc is the main, or sole, constituent of infectious prions. LÄS MER
5. Changed iron metabolism and iron toxicity in scrapie-infected neuroblastoma cells
Sammanfattning : Reactions and interactions of iron and oxygen can be both beneficial and detrimental to cells and tissues. Iron is mainly found in our blood where it functions as a mediator in the transport of oxygen to the cells and is further vital for the cellular respiration reducing the oxygen to water. LÄS MER