Sökning: "Fyn"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet Fyn.

  1. 1. Interactions of Prion Proteins and PrP-derived Peptides in Scrapie infection

    Författare :Kajsa Löfgren Söderberg; Astrid Gräslund; Marcus Fändrich; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Spongiform encephalopathy; Creutzfeldt-Jakob disease; Amyloidosis; Neurodegeneration; Cell penetrating peptide; Protein Transduction Domain; Heparan sulfate; Proteoglycan; Glypican; Src family kinase; Fyn; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Prion diseases are fatal and incurable spongiform encephalopathies that occur amongst mammals. The central pathological event is the misfolding of the cellular prion protein (PrPC) into an amyloid, neurotoxic isoform called scrapie (PrPSc). PrPSc is the main, or sole, constituent of infectious prions. LÄS MER

  3. 2. Prion-infection and Cellular Signaling : Influence of scrapie-infection on lipid raft-associated proteins

    Författare :Hanna Gyllberg; Katarina Bedecs; Albert Taraboulos; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Prion diseases are a group of fatal neurodegenerative diseases affecting almost all mammals including humans. The diseases are caused by formation of the misfolded isoform of the cellular prion protein (PrPC) to the disease causing PrPSc. LÄS MER

  4. 3. Regulatory aspects of innate immune responses

    Författare :Ahmed El Marghani; Per-Erik Olsson; Peter Kjellén; Muhammad Zafarullah; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Innate immunity; TOM1L1; inflammatory responses; Biology; Biologi;

    Sammanfattning : Activation of innate immunity is regulated by a variety of signaling molecules within the immune cells. The present thesis was aimed to improve our understanding of innate signaling mechanism and their possible use as bio-indicators of exposure and disease. LÄS MER

  5. 4. Shards of Iron Age Communications. A ceramological study of internal structures and external contacts in the Gudme-Lundeborg Area, Funen during the Late Roman Iron Age

    Författare :Ole Stilborg; Arkeologi; []
    Nyckelord :HUMANIORA; HUMANITIES; local; Funen; Gudme-Lundeborg Area; trading site; cemetery; settlement; Late Roman Iron Age; material systems; Things; communication; Pottery; ceramology; import; center; Archaeology; Arkeologi;

    Sammanfattning : The objective of ceramology is to describe pottery craft traditions; the potters, their production, social organisation and the use of the products. Through this the human actions surrounding the pottery are studied. LÄS MER

  7. 5. T cells in patients with B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) : an immunological study

    Författare :Shahryar Kiaii; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :T cell; B-cell Chronic Lymphocytic Leukemia ; Multiple Myeloma ; signaling; gene expression;

    Sammanfattning : There are several lines of evidence that T cells in patients with Multiple Myeloma (MM) and B-cell Chronic Lymphocytic Leukemia (B-CLL) are phenotypically aberrant. The overall aim of this thesis was to study T cells with a focus on TCR-signaling pathways in these two B-cell malignancies. The role of T-cells in B-CLL etiology was also examined. LÄS MER