Sökning: "reumatoid artrit"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden reumatoid artrit.

  1. 1. Early rheumatoid arthritis : biomarkers and hormonal factors in relation to disease progression

    Författare :Antonia Boman; Solbritt Rantapää-Dahlqvist; Ewa Berglin; Gerd-Marie Alenius; Mikael Brink; Heidi Kokkonen; Inger Gjertsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early rheumatoid arthritis; biomarker; ACPA; RANKL; disease activity; radiological destruction; cardiovascular events; hormonal factors; reumatologi; rheumatology;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, affecting approximately 0.5 to 1% of the adult population. Although the aetiology is not fully known, a complex interaction between genetic, environmental and stochastic factors is thought to trigger the pathogenic mechanisms. LÄS MER

  3. 2. Participation and support in everyday life over a decade : perspectives of persons with rheumatoid arthritis and their significant others

    Författare :Maria Bergström; Mathilda Björk; Annette Sverker; Åsa Larsson Ranada; Stefan Bergman; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Activities; Everyday life; Longitudinal research; Participation; Rehabilitation; Rheumatoid arthritis; Significant Others; Support; Work; Aktiviteter; Arbete; Delaktighet; Longitudinell forskning; Närstående; Rehabilitering; Reumatoid artrit; Stöd; Vardagliga livet;

    Sammanfattning : Introduction: The treatment of rheumatoid arthritis (RA) has evolved over recent decades. Today, many previous limitations related to, for example, joint damage have become rare, and persons with RA can often continue to work and engage in different aspects of everyday life. LÄS MER

  4. 3. Focus on Chronic Disease through Different Lenses of Expertise : Towards Implementation of Patient-Focused Decision Support Preventing Disability: The Example of Early Rheumatoid Arthritis

    Författare :Örjan Dahlström; Toomas Timpka; Ingrid Thyberg; Ursula Hass; Ingemar Petersson; Linköpings universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Clinical Decision Support; Rheumatology; Prognosis; Disability; Fatigue; Knowledge Engineering; Kliniskt beslutsstöd; reumatologi; prognos; funktionshinder; trötthet; kunskapsmodellering; Disability research; Handikappsforskning;

    Sammanfattning : Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease. Treatment strategies emphasize early multi-professional interventions to reduce disease activity and to prevent disability, but there is a lack of knowledge on how optimal treatment can be provided to each individual patient. LÄS MER

  5. 4. Presence of immunological markers preceding the onset of rheumatoid arthritis

    Författare :Mikael Brink; Solbritt Rantapää Dahlqvist; Anca Irinel Catrina; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoantibodies; rheumatoid arthritis; anti citrullinated protein antibodies; pre-symptomatic individual; immunologi; Immunology; reumatologi; rheumatology;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease with an unknown aetiology characterized by joint destruction. Both genetic and environmental factors contribute to the disease development with HLA-DRB1* alleles and smoking identified as most important. LÄS MER

  7. 5. Cartilage proteins and their arthritogenic properties in arthritis

    Författare :Stefan Carlsén; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; HLA-DR4; tolerance; COMP; CXI; CIX; arthritis; Cartilage; collagen;

    Sammanfattning : In this thesis the role of cartilage proteins and their potential as antigen and availability to the immune system in arthritis were investigated. Six papers are included; where four present new animal models for Rheumatoid arthritis (RA), one shows how genetic disorders in cartilage may affect arthritis and the last how posttranslational modification of collagen type II (CII) affects tolerance. LÄS MER