Sökning: "retroviral mediated gene expression"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden retroviral mediated gene expression.

  1. 1. Vector development for suicide gene therapy

    Författare :Alar Aints; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

    Sammanfattning : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. LÄS MER

  3. 2. Regulation of hematopoiesis by the Smad signaling pathway

    Författare :Ulrika Blank Savukinas; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; retroviral mediated gene expression; conditional knockout; hematopoietic stem cell; hematopoiesis; Transforming growth factor-beta; Smad signaling; Medicin människa och djur ;

    Sammanfattning : Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and are ultimately responsible for the continuous production of blood cells throughout life. The regulation of HSCs in vivo is tightly regulated by both intrinsic and extrinsic factors. LÄS MER

  4. 3. Smad signaling in hematopoietic stem cell biology

    Författare :Göran Karlsson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Smad7; Smad4; microarray; retroviral-mediated gene expression; conditional knockout; transforming growth factor beta; smad signaling; hematopoiesis; hematopoietic stem cells; Alk5; Medicine human and vertebrates ; Medicin människa och djur ;

    Sammanfattning : Hematopoietic stem cells (HSCs) are primitive tissue-specific somatic stem cells, responsible for the maintenance and replenishment of the bone marrow (BM) and subsequently the entire blood system. The never-ending ability to differentiate into all the mature hematopoietic lineages makes these HSCs attractive candidates for use in future regenerative medicine. LÄS MER

  5. 4. HOST EPIGENETIC REGULATOR BMI1 AND VIRAL FIBER PROTEIN FOR EQUILIBRIUM BETWEEN ADENOVIRUS AND HOST

    Författare :Manli Na; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; BMI1; Dual-gene expression; Epigenetic; Equilibrium; Fiber; HSC; HDAC; TSA;

    Sammanfattning : Human adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. LÄS MER

  7. 5. Semliki forest virus-derived packaging system for production of retroviral vectors

    Författare :Ke-Jun Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Moloney murine leukemia virus; Semliki Forest virus; gene therapy; retroviral vector; intron; human bone marrow stromal cell;

    Sammanfattning : Gene therapy is a treatment of disease by transfer of genetic material into somatic cells of an individual. Successful gene therapy depends on a delivery system which can efficiently transfer the gene into target cells and lead to high level expression of the gene. LÄS MER