Sökning: "radionuclide molecular imaging"

Visar resultat 11 - 15 av 32 avhandlingar innehållade orden radionuclide molecular imaging.

1. 11. Affibody-mediated targeting of HER-family receptors for cancer imaging and therapy

   Författare :Charles Dahlsson Leitao; Stefan Ståhl; John Löfblom; Christoph Rader; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer therapy; radionuclide imaging; affibody molecules; HER-receptors; prodrug; protein design; Cancerterapi; radionuklidavbildning; affibody molekyler; HER-receptorer; prodrog; proteindesign; Bioteknologi; Biotechnology;

   Sammanfattning : Proteins are remarkable molecules with diverse and specialized functions playing essential roles in most biological processes. One such function is protecting us from diseases by the action of antibodies in our immune system that can recognize and mediate the destruction of invading pathogens by binding to foreign epitopes found on non-self proteins. LÄS MER

3. 12. Design and Evaluation of Radiolabeled Affibody Tracers for Imaging of HER2-expressing Tumors

   Författare :Helena Wållberg; Stefan Ståhl; Dario Neri; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; radionuclide molecular imaging; HER2; radiotracer; SPECT; PET; biodistribution; protein engineering; radiolabeling;

   Sammanfattning : The growing understanding of tumor biology and the identification of tumor specificgenetic and molecular alterations, such as the overexpression of human epidermal growthfactor receptor 2 (HER2), opens up for personalization of patient management using targeted therapies. However, this puts stringent demands on the diagnostic tools usedto identify patients that are likely to respond to a particular treatment. LÄS MER

4. 13. Radiolabelled affibody molecules for imaging EGFR expression in tumours

   Författare :Maryam Oroujeni; Vladimir Tolmachev; Martin Behe; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecules; ZEGFR:2377; radionuclide molecular imaging; PET; SPECT; labelling chemistry.;

   Sammanfattning : Affibody molecules are promising scaffold-based targeting proteins for radionuclide imaging and cancer therapy. This thesis is based on 5 original research articles (Papers I-V), with the primary focus being placed on the optimization of molecular design of EGFR-binding affibody variants for high contrast imaging of epidermal growth factor receptor (EGFR) expression in tumours. LÄS MER

5. 14. The ADAPT scaffold as a tool for diagnostic imaging and targeted therapy

   Författare :Emma von Witting; Sophia Hober; Inger Sandlie; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein G; ABD; ADAPT; affinity proteins; antibody; protein engineering; targeted therapy; nuclear medicine; molecular imaging; HER2; radionuclide therapy; Bioteknologi; Biotechnology;

   Sammanfattning : Molecular recognition, or the specific interactions between a protein and its ligand, is central to biology and a key factor for many different clinical and technical applications. Despite antibodies being only one of many different affinity proteins, it has by far been the most successful. LÄS MER

7. 15. Antibody Mediated Radionuclide Targeting of HER-2 for Cancer Diagnostics and Therapy : Preclinical Studies

   Författare :Mikael Persson; Per-Uno Malmström; Vladimir Tolmachev; Jörgen Carlsson; Marion De Jong; Uppsala universitet; []
   Nyckelord :Molecular medicine; Neoplasm Antibodies; Targeted Radiotherapy; Radionuclide Imaging; Molekylärmedicin;

   Sammanfattning : Targeted radionuclide therapy (TRT) holds great promise for the treatment of cancer. In TRT, radioactive nuclides are delivered specifically to tumours by molecules that recognise and bind to structures overexpressed by, or specific to, cancer cells. LÄS MER