Sökning: "radionuclide molecular imaging"
Visar resultat 21 - 25 av 32 avhandlingar innehållade orden radionuclide molecular imaging.
21. Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure
Sammanfattning : Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. LÄS MER
22. Tumour Targeting using Radiolabelled Affibody Molecules : Influence of Labelling Chemistry
Sammanfattning : Affibody molecules are promising candidates for targeted radionuclide-based imaging and therapy applications. Optimisation of targeting properties would permit the in vivo visualization of cancer-specific surface receptors with high contrast. In therapy, this may increase the ratio of radioactivity uptake between tumour and normal tissues. LÄS MER
23. Liquid Chromatography – Mass Spectrometry Analysis of Short-lived Tracers in Biological Matrices : Exploration of Radiotracer Chemistry as an Analytical Tool
Sammanfattning : Liquid chromatography – mass spectrometry (LC-MS) methods were developed for the analysis of positron emission tomography (PET) radiotracers in biological matrices. Additionally, radiotracer chemistry was explored as an analytical tool for supporting LC-MS method development and imaging molecular interactions in miniaturised chemical analysis systems. LÄS MER
24. Generation and engineering of ABD-derived affinity proteins for clinical applications
Sammanfattning : Proteins that specifically recognize and bind to other molecules or structures are important tools in industrial and medical applications. Binding proteins engineered from small stable scaffold proteins have been utilized for several purposes due to their favorable biophysical properties, tolerance to mutagenesis, efficient tissue penetration and ease of production. LÄS MER
25. Radiolabeled HER-2 Binding Affibody Molecules for Tumor Targeting : Preclinical Studies
Sammanfattning : Conventional cancer treatment based on radiotherapy or chemotherapy affects all dividing cells. By directing the therapy specifically to the tumor cells, normal cells can be spared. Tumor targeting molecules carrying a cytotoxic moiety is then an attractive approach. LÄS MER