Sökning: "precursor protein"

Visar resultat 1 - 5 av 257 avhandlingar innehållade orden precursor protein.

  1. 1. Systems biology of protein synthesis and secretion in yeast

    Författare :Qi Qi; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; multi-omics analysis; protein secretion; genome-scale modeling; recombinant protein production; protein synthesis;

    Sammanfattning : Protein synthesis and secretion is a vital process to maintain cell function. As it demands numerous building blocks, cofactors and chaperones generated from metabolism and translation, the process is intertwined with metabolic and regulatory networks. LÄS MER

  2. 2. Physiological role of amyloid precursor protein during neural development

    Författare :Rakesh Kumar Banote; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid precursor protein; Zebrafish; Spinal cord; Motor neurons; Hindbrain; Mauthner cell; Development; Proteomics;

    Sammanfattning : Amyloid precursor protein (APP) is a type-one membrane-spanning protein with a large extracellular N-terminal domain and a small intracellular C-terminal domain. APP first gained interest due to its involvement in the pathogenesis of Alzheimer’s disease (AD). LÄS MER

  3. 3. Metabolic Engineering of Recombinant Protein Production by Saccharomyces cerevisiae

    Författare :Zihe Liu; Chalmers University of Technology; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; recombinant protein production; genome sequencing; DNA microarray; insulin precursor; growth rate; UV mutation; yeast; anaerobic electron acceptor; secretory pathway; unfolded protein response; metabolic engineering; systems biology; α-amylase;

    Sammanfattning : The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels, chemicals, and it also provides a platform for the production of many heterologous proteins of medical or industrial interest. In this thesis, random and rational approaches, such as vector design, host engineering, fermentation analysis, UV Mutation, coupled with high-throughput systems biology techniques (including whole genomic sequencing, microarray analysis and flux analysis) and integrated analysis (Reporter feature technique), were employed to engineer cellular properties more effectively and purposefully to construct cell factories for protein production. LÄS MER

  4. 4. Innate Immune Proteins in a Crustacean Pacifastacus leniusculus

    Författare :Chenglin Wu; Irene Söderhäll; petr Kopácek; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; 2-DE; hematopoiesis; marker protein; melaniztion inhibiting protein; proPO-system; pattern recognition protein; PGN; ficolin-like protein; Immunology; Immunologi; Biology with specialization in Comparative Physiology; Biologi med inriktning mot jämförande fysiologi;

    Sammanfattning : Hemocytes (blood cells) are important in the immune defense against pathogens in invertebrates. In crusteacean, the hemocytes and plasma components mount a strong innate immune response against different pathogens including bacteria and virus. LÄS MER

  5. 5. Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease

    Författare :Annika Olsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Alzheimer s disease; amyloid precursor protein; ß-amyloid; biomarker; cerebrospinal fluid; enzyme-linked immunosorbent assay; plasma;

    Sammanfattning : Alzheimer s disease (AD) is a neurodegenerative disorder characterised by accumulations of neurofibrillary tangles and amyloid plaques. The major components of the amyloid deposits are the ß-amyloid (Aß) peptides derived from the amyloid precursor protein (APP). LÄS MER