Sökning: "mtDNA"

Visar resultat 36 - 40 av 111 avhandlingar innehållade ordet mtDNA.

1. 36. Sudden infant death syndrome : a medico-legal study of related cardiovascular, toxicological and genetic findings

   Författare :Petra Råsten Almqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cardiovascular malformation; Cotinine; Heart weight; mtDNA; Myocarditis; Nicotine; SIDS;

   Sammanfattning : The present medico-legal investigation of the deaths of infants less than one year of age was designed to enhance our understanding of the Sudden Infant Death Syndrome (SIDS). Special emphasis was placed on the significance of cardiovascular pathology (including heart weight, malformations and myocarditis); exposure to nicotine; and mutations and/or polymorphisms in mitochondrial DNA (mtDNA). LÄS MER

3. 37. Molecular mechanisms for transcription in mammalian mitochondria

   Författare :Martina Gaspari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :mitochondria; oxidative phosphorylation; mtDNA; transcription; TFAM; TFB1M TFB2M; POLRMT; promoter recognition; CSB II;

   Sammanfattning : The circular double stranded mitochondrial genome (mtDNA), which is about 16,600 bp in humans and 16,300 bp in mice, encodes 13 of the -90 different proteins present in the respiratory chain of mammalian mitochondria. The remaining components of the respiratory chain are encoded by nuclear genes and imported into the mitochondrial network. LÄS MER

4. 38. Life without mitochondrial DNA : studies of transgenic mice

   Författare :Jianming Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcripton factor A Tfam ; cre-loxP; conditional knockout; transgenic; mitochondrial cardiomyopathy; apoptosis;

   Sammanfattning : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. LÄS MER

5. 39. Mitochondrial dysfunction and alterations of brain HMPAO SPECT in depressive disorder : perspectives on origins of 'somatization'

   Författare :Ann Gardner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :99mTc-d; 1-hexamethylpropyleneamine oxime; clinical rating scales; hearing loss; mtDNA; muscle biopsy; PCR; single photon emission computed tomography; tinnitus; unipolar depression.;

   Sammanfattning : A range of somatic symptoms are more common in patients with major depression than in the general population. Similar somatic symptoms and depression have been described in mitochondrial disorders, in which decreased production of adenosine triphosphate (ATP) is found. LÄS MER

7. 40. Evolutionary History of the Root Vole (Microtus oeconomus) as Revealed by Y Chromosome and Mitochondrial DNA sequences

   Författare :Cecilia Brunhoff; Malmö Patologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; colonization history; phylogeography; root vole; cytogenetics; Genetik; cytogenetik;

   Sammanfattning : The root vole (Microtus oeconomus) is a rodent with Holarctic distribution. In fact, it is the only Microtus vole found in both Eurasia and North America. Phylogeographic analyses of the root vole from across its distribution range were performed using mitochondrial and Y chromosome DNA sequences. LÄS MER