Sökning: "mtDNA"

Visar resultat 1 - 5 av 96 avhandlingar innehållade ordet mtDNA.

1. 1. Crisis in Energy Metabolism - Mitochondrial Defects and a New Disease Entity

   Författare :Gittan Kollberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Mitochondrial Disorders; mtDNA; multiple mtDNA deletions; Alpers-Huttenlocher syndrome; POLG1; GYS1; glycogen synthase; point mutation; Polymerase gamma;

   Sammanfattning : Impairment of energy metabolism may be associated with severe implications for affected individuals since all fundamental cell functions are energy-dependent. Disorders of energy metabolism are often genetic and associated with defects in the oxidative phosphorylation in mitochondria. LÄS MER

3. 2. Analysis of the origin and spread of the domestic dog using Y-chromosome DNA and mtDNA sequence data

   Författare :Mattias Oskarsson; Peter Savolainen; Ben Sacks; KTH; []
   Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; mtDNA; domestication; Y-chromosome; SNP; ASY; dog; dingo;

   Sammanfattning : The domestic dog was probably the first domesticated animal, and the only one to spread to all continents in ancient times. The dog is one of the most phenotypically diverse animals, a result of human selection throughout dog history. LÄS MER

4. 3. Analysis of domestic dog mitochondrial DNA sequence variation for forensic investigations

   Författare :Helen Angleby; KTH; []
   Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; Biotechnology; forensics; mtDNA; control region; hair; domestic dog; breed; Bioteknik; Bioengineering; Bioteknik;

   Sammanfattning : The first method for DNA analysis in forensics was presented in 1985. Since then, the introduction of the polymerase chain reaction (PCR) has rendered possible the analysis of small amounts of DNA and automated sequencing and fragment analysis techniques have facilitated the analyses. LÄS MER

5. 4. Initiation of Mammalian Mitochondrial DNA Replication

   Författare :Elisabeth Jemt; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondria; mtDNA; DNA replication;

   Sammanfattning : Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and they contain their own genome. The mitochondrial DNA (mtDNA) is a double stranded circular molecule that codes for proteins required for cellular respiration and RNA molecules involved in translation of these proteins. LÄS MER

7. 5. Inflammatogenic properties of endogenous DNA

   Författare :Shahin Hajizadeh; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Nyckelord :Inflammation; mtDNA; oxidized DNA; SF; CSF; RA; dementia;

   Sammanfattning : Bacterial DNA and CpG-containing oligodeoxynucleotides (ODNs) induce host inflammatory responses as a result of their content of unmethylated ¡§CpG motifs¡¨. Since the CpG motifs in the mitochondrial (mt) genome are in this respect similar to bacterial DNA, in that they are non-methylated, we investigated whether mtDNA also displays inflammatogenic potential. LÄS MER