Sökning: "Jianming Wang"

Hittade 1 avhandling innehållade orden Jianming Wang.

1. 1. Life without mitochondrial DNA : studies of transgenic mice

   Författare :Jianming Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcripton factor A Tfam ; cre-loxP; conditional knockout; transgenic; mitochondrial cardiomyopathy; apoptosis;

   Sammanfattning : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. LÄS MER