Sökning: "mouse"

Visar resultat 11 - 15 av 2230 avhandlingar innehållade ordet mouse.

  1. 11. Imaging of coronary artery function and morphology in living mice - applications in atherosclerosis research

    Författare :Johannes Wikström; Göteborgs universitet; []
    Nyckelord :atherosclerosis; coronary artery; coronary flow velocity reserve; imaging; mouse; transthoracic Doppler echocardiography; ultrasound biomicroscopy;

    Sammanfattning : Atherosclerosis in the coronary arteries is the major reason for myocardial infarction and cardiovascular death. In the clinic, several imaging systems make it possible to study coronary artery function and morphology non-invasively, such as transthoracic Doppler echocardiography (TTDE). LÄS MER

  3. 12. Low-Dose Ionizing Radiation Induces Neurotoxicity in the Neonate : Acute or fractionated doses and interaction with xenobiotics in mice

    Författare :Sonja Buratovic; Per Eriksson; Henrik Viberg; Bo Stenerlöw; Anders Fredriksson; Jean-René Jourdain; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ionizing radiation; Neonatal; Neurotoxicity; Behaviour; Nicotine; Ketamine; Mouse; Cognition; Acute irradiation; Fractionated irradiation;

    Sammanfattning : This thesis examines the developmental neurotoxic effects of exposure to low-dose ionizing radiation (IR), alone or together with xenobiotics, during a critical period of neonatal brain development in mice.During mammalian brain development there is a period called the brain growth spurt (BGS), which involves extensive growth and maturation of the brain. LÄS MER

  4. 13. Cellular Interactions with Extracellular Matrix During Development and in Muscle Disease

    Författare :Carl-Fredrik Tiger; Anders Aspberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; integrin; laminin; collagen; muscle; tendon; skeleton; mouse; human; development; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The formation and maintenance of tissues in multicellular animals are crucially dependent on cellular interactions with the extracellular matrix (ECM). Two different studies on such interactions are presented herein. LÄS MER

  5. 14. Measurement of T1 relaxation time in lungs - Preclinical and clinical MRI applications to COPD

    Författare :Daniel Alamidi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Magnetic Resonance Imaging; biomarker; tobacco smoke; mouse; smoking; lung imaging; Chronic Obstructive Pulmonary Disease; ultrashort echo time UTE ; T1 mapping; longitudinal relaxation time;

    Sammanfattning : Monitoring of regional lung function in clinical trials of chronic obstructive pulmonary disease (COPD) requires alternative endpoints beyond global pulmonary function tests (PFTs), which is the most common approach for diagnosing lung function abnormalities in humans. A promising magnetic resonance imaging (MRI) biomarker of lung disease in humans and animals is the T1 relaxation parameter. LÄS MER

  7. 15. Immunotherapy against malignant brain tumors - of mice and men

    Författare :Karin Enell Smith; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor Immunology; Immunotherapy; Glioma; Mouse;

    Sammanfattning : Glioblastoma Multiforme (GBM) is the most abundant and most aggressive primary brain tumor in adults. Due to the infiltrative growth of the tumor, surgery will never be radical. Radiation and chemotherapy only marginally improve the poor prognosis due to the ability of the GBM to develop resistance towards these treatments. LÄS MER