Sökning: "mouse model"

Visar resultat 16 - 20 av 1145 avhandlingar innehållade orden mouse model.

  1. 16. Metab-Immune analysis of the non-obese diabetic mouse

    Författare :Viqar Banday; Kristina Lejon; Åsa Andersson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NOD mouse; Type 1 diabetes; B cells; glutamic acid; metabolomics; immunologi; Immunology;

    Sammanfattning : Type 1A diabetes mellitus or T1D is a chronic disease characterized by T cell mediated destruction of the insulin producing β cells in the islets of Langerhans. The classical symptoms include high glucose levels in urine and blood, polyuria, and polydipsia. LÄS MER

  3. 17. Modelling of muscular force induced by non-isometric contraction

    Författare :Natalia Kosterina; Anders Eriksson; Michael Günther; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Skeletal muscle; Muscular force; Concentric contractions; Eccentric con- tractions; History effect; Force modification; Muscle model; Musculoskeletal model;

    Sammanfattning : The main objective of the study was to investigate and simulate skeletal muscleforce production during and after isometric contractions, active muscle lengtheningand active muscle shortening. The motivation behind this work was to improve thedominant model of muscle force generation based on the theories of Hill from 1938. LÄS MER

  4. 18. Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System

    Författare :Björn Jansson; Erik Björk; Sveinbjörn Gizurarson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Administration; intranasal; Nasal mucosa; Central nervous system; Olfactory bulb; Rat; Mouse; Swine; Cattle; Diffusion chambers; culture; In vitro; Biological models; Biological transport; Dextrans; Dopamine; Gels; Polysaccharides; Autoradiography; Fluorescence microscopy; Biofarmaci; Biopharmacy; Biofarmaci;

    Sammanfattning : The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer. LÄS MER

  5. 19. The roles of the plasminogen activator and matrix metalloproteinase systems in ovulation and corpus luteum formation

    Författare :Ida Bodén; Umeå universitet; []
    Nyckelord :ovary; ovulation; corpus luteum; plasminogen; PA; MMP; mouse;

    Sammanfattning : Proteases of the plasminogen activator (PA) and the matrix metalloproteinase (MMP) enzyme systems are expressed in the ovulatory follicle and in the developing corpus luteum (CL). However, the functional role of these extracellular degrading protease systems in the ovulatory and CL development processes remains elusive. LÄS MER

  7. 20. Immunotherapy against malignant brain tumors - of mice and men

    Författare :Karin Enell Smith; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor Immunology; Immunotherapy; Glioma; Mouse;

    Sammanfattning : Glioblastoma Multiforme (GBM) is the most abundant and most aggressive primary brain tumor in adults. Due to the infiltrative growth of the tumor, surgery will never be radical. Radiation and chemotherapy only marginally improve the poor prognosis due to the ability of the GBM to develop resistance towards these treatments. LÄS MER