Sökning: "mouse model"

Visar resultat 11 - 15 av 1144 avhandlingar innehållade orden mouse model.

  1. 11. Calpain-Mediated Apoptosis in Motor Neurons of Adult Mouse Spinal Cord Slices

    Författare :HamidReza Momeni; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Calpain; Djurfysiologi; Animal physiology; Spinal cord; Organ culture; Mouse; Motor neurons; Caspase; Calpain inhibitor; Calpain activity; Apoptosis;

    Sammanfattning : Motor neuron degeneration is a critical phenomenon during spinal cord injuries and some neurodegenerative diseases. However, the mechanisms by which cell death is induced in these neurons are poorly understood. LÄS MER

  3. 12. Cellular and molecular mechanisms in immune mediated hepatic fibrosis. A study of the inflammatory syndrome and fibrosis development of the NIF mouse liver

    Författare :Julia Nilsson; Autoimmunitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibrosis; liver; mouse model; NKT cells; type 2 inflammation; inflammasome;

    Sammanfattning : Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. LÄS MER

  4. 13. Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer

    Författare :Zhiyuan V. Zou; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; ApcMin mouse;

    Sammanfattning : Colorectal cancer (CRC) is a cancer that occurs in the colon or rectum and is one of the most common cancer forms and a leading cause of cancer death in the Western world. The majority of CRCs are caused by inherited or somatic mutations in the APC gene. LÄS MER

  5. 14. Anomalies in humoral immunity in the NOD mouse : contribution to the progression of type 1 diabetes

    Författare :Radha Thyagarajan; Kristina Lejon; Per-Arne Oldenborg; Susanna Cardell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; NOD mouse; B cells; IgE; TACI; BAFF; immunologi; Immunology;

    Sammanfattning : The non-obese diabetic (NOD) mouse is widely used model Type 1 diabetes (T1D), a chronic inflammatory disease characterized by destruction of the insulin producing β cells in the islets of Langerhans by immune cells. The classical symptoms include increased glucose levels in urine and blood, frequent urination and enhanced thirst. LÄS MER

  7. 15. A mouse model for direct evaluation of cholera vaccines

    Författare :Erik Nygren; Göteborgs universitet; []
    Nyckelord :Vibrio cholerae; cholera vaccine; cholera toxin; LPS; anti-bacterial immunity; IgA; challenge; protection; colonization;

    Sammanfattning : Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup can cause disease due to their ability to colonize the intestine and produce an enterotoxin, cholera toxin (CT). LÄS MER