Sökning: "glutamic acid"

Visar resultat 1 - 5 av 75 avhandlingar innehållade orden glutamic acid.

1. 1. Metab-Immune analysis of the non-obese diabetic mouse

   Författare :Viqar Banday; Kristina Lejon; Åsa Andersson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NOD mouse; Type 1 diabetes; B cells; glutamic acid; metabolomics; immunologi; Immunology;

   Sammanfattning : Type 1A diabetes mellitus or T1D is a chronic disease characterized by T cell mediated destruction of the insulin producing β cells in the islets of Langerhans. The classical symptoms include high glucose levels in urine and blood, polyuria, and polydipsia. LÄS MER

3. 2. Effects of antipsychotics on GABA neurons in the basal ganglia of the rat

   Författare :Jiang Yu; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; antipsychotics; γ-aminobutyric acid; glutamic acid decarboxylase; basal ganglia; entopeduncular nucleus; vacuous chewing movements; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

   Sammanfattning : Antipsychotics are used in the treatment of psychosis and, based on their propensities to induce extrapyramidal side effects (EPS), are divided into typical (haloperidol) and atypical (clozapine) subtypes. The incidence of EPS, arises from an imbalance in the neurotransmission between two majorGABAergic pathways of the basal ganglia that connect the striatum directly to the entopeduncular nucleus (EP) and the substantia nigra reticulata or indirectly via the globus pallidus and the subthalamic nucleus. LÄS MER

4. 3. Characterizing Elongation of Protein Synthesis and Fusidic Acid Resistance in Bacteria

   Författare :Srihari Nagendra Ravi Kiran Koripella; Suparna Sanyal; Daniel Wilson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Elongation factor-G; FusB; GTP; Staphylococcus aureus; Escherichia coli and Fusidic acid; Molecular Biology; Molekylärbiologi;

   Sammanfattning : Protein synthesis is a highly complex process executed by the ribosome in coordination with mRNA, tRNAs and translational protein factors. Several antibiotics are known to inhibit bacterial protein synthesis by either targeting the ribosome or the proteins factors involved in translation. LÄS MER

5. 4. Clinical, Genetic and Metabolic Characterisation of LADA (Latent Autoimmune Diabetes in Adults)

   Författare :ÅsaLinda Lethagen; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolic syndrome; insulin sensitivity; insulin secretion; GADabs; glutamic acid decarboxylase autoantibodies; Type 2 diabetes; LADA; Type 1 diabetes; IDDM1; IDDM2; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Latent autoimmune diabetes in adults (LADA) comprises about 10% of patients initially diagnosed with type 2 diabetes but who are positive for pancreatic islet antibodies, especially to glutamic acid decarboxylase (GADabs). The present studies focused on clinical, genetic and metabolic characterisation of patients with LADA. LÄS MER

7. 5. Immunogenetics of Childhood Type 1 Diabetes in Immigrant Patients in Sweden. Migration Studies on Type 1 Diabetes

   Författare :Ahmed Delli; Celiaki och diabetes; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Type 1 Diabetes; Childhood; Human Leukocyte Antigen HLA ; Islet autoantibodies; Zinc Transporter 8 ZnT8 ; Islet antigen IA2- ; Glutamic Acid Decarboxylase 65 GAD65; Insulin; Migration.;

   Sammanfattning : This thesis examined whether the offspring of immigrants (non-Swedes) to Sweden are at increased risk of Type 1 Diabetes (T1D) when they are born or live in Sweden. It also evaluated if their T1D and T2D-related genes differed from Swedish patients and whether this genetic heritage determined the types and existence of islet autoantibodies at time of diagnosis and affected the classification of diabetes. LÄS MER