Sökning: "molekylär evolution"

Visar resultat 41 - 45 av 125 avhandlingar innehållade orden molekylär evolution.

  1. 41. Meiotic Recombination in Human and Dog : Targets, Consequences and Implications for Genome Evolution

    Författare :Jonas Berglund; Matthew Webster; Kerstin Lindblad-Toh; Leif Andersson; Nadia Singh; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; recombination; biased gene conversion; CpG island; copy number variation; substitutions; methylation; Bioinformatics; Bioinformatik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Understanding the mechanism of recombination has important implications for genome evolution and genomic variability. The work presented in this thesis studies the properties of recombination by investigating the effects it has on genome evolution in humans and dogs. LÄS MER

  3. 42. Enzyme Cold Adaptation through Evolution of Protein Flexibility

    Författare :Jaka Sočan; Johan Åqvist; Hugo Gutiérrez-de-Terán; Janez Mavri; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EVB; Empirical valence bond method; Pancreatic elastase; α-amylase; Enzyme catalysis; Enzyme evolution; Cold adaptation; Temperature dependence of catalytic rates; Psychrophilic enzyme; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : What lives, evolves. Macromolecular catalysis is a process, central to both evolutionary and metabolic aspect of life, as it provides a systematic bias favouring certain chemical processes. LÄS MER

  4. 43. Towards renewable chemicals production in cyanobacteria

    Författare :Kateryna Kukil; Pia Lindberg; Yu Jianping; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Synechocystis PCC 6803; metabolic engineering; succinate; phenylpropanoids; laboratory evolution; Chemistry with specialization in Molecular Biomimetics; Kemi med inriktning mot molekylär biomimetik;

    Sammanfattning : The intensive fossil fuel combustion by humanity resulted in the increase of atmospheric CO2 concentration creating the greenhouse effect, which in turn causes severe environmental problems. Thus, humanity should find solutions to decrease dependency on fossil hydrocarbons in order to lower CO2 emission into the atmosphere. LÄS MER

  5. 44. Tissue Microarrays for Analysis of Expression Patterns

    Författare :Cecilia Lindskog Bergström; Fredrik Pontén; Anna Asplund; Ari Ristimäki; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue microarrays; Antibody-based proteomics; Immunohistochemistry; Biomarker discovery; Diabetes; Lung cancer; Influenza virus; Evolution; Pathology; Patologi;

    Sammanfattning : Proteins are essential building blocks in every living cell, and since the complete human genome was sequenced in 2004, researchers have attempted to map the human proteome, which is the functional representation of the genome. One such initiative is the Human Protein Atlas programme (HPA), which generates monospecific antibodies towards all human proteins and uses these for high-throughput tissue profiling on tissue microarrays (TMAs). LÄS MER

  7. 45. NMR Studies of Bacterial Albumin-Binding Modules

    Författare :Maria U Johansson; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fysikalisk kemi; Biotechnology; Bioteknik; Proteins; enzymology; Proteiner; enzymologi; Physical chemistry; three-helix bundle; protein structure; protein PAB; protein-protein interactions; protein G; protein dynamics; NMR; module shuffling; GA module; evolution; albumin-binding; bacterial surface proteins;

    Sammanfattning : Peptostreptococcus magnus and group C/G streptococci are Gram-positive cocci that are part of the normal flora and reside in more or less the same locations in the host. Protein G of group C/G streptococci was originally described as binding IgGFc of several species and later shown to also bind human serum albumin and albumins from various animal species. LÄS MER