Sökning: "molecular pathology"

Visar resultat 26 - 30 av 265 avhandlingar innehållade orden molecular pathology.

1. 26. Expression and functional analysis of the SCA7 disease protein ataxin-7

   Författare :Anna-Lena Ström; Monica Holmberg; Patrik Brundin; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Polyglutamine disease; CAG repeat; Spinocerebellar ataxia type 7; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disease characterized by cerebellar ataxia and visual problems due to a progressive and selective loss of neurons within the cerebellum, brainstem and retina. The disease is caused by the expansion of a CAG repeat in the first coding exon of the SCA7 gene, resulting in an expanded polyglutamine domain in the N-terminal part of ataxin-7, a protein of unknown function. LÄS MER

3. 27. Studies on the biological functions of interaction between components in Wnt, TGF-β and HIF pathways for cancer progression

   Författare :Karthik Aripaka; Maréne Landström; Jonas von Hofsten; Carl-Henrik Heldin; Ruth Palmer; Lars-Gunnar Larsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TRAF6; HIF-1α; HIF-2α; HIF-3α; ALK5; Wnt3a; Hypoxic signalling; TGF-β; zebrafish; β-Catenin; Pathology; patologi; Oncology; onkologi;

   Sammanfattning : Cancer is a disease that involves aggressive changes in the genome and aberrant signals between the living cells. Signalling pathways such as TGF-β (Transforming growth factor-β), Wnt, EGF (epidermal growth factor) and HIF (Hypoxia-inducible factor) evolved to regulate growth and development in mammals. LÄS MER

4. 28. Analysis of Sun-Damaged Skin and Epidermal p53 Clones

   Författare :Helena Bäckvall; Nicole Basset-Seguin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Patologi; Pathology; Patologi; Pathology; patologi;

   Sammanfattning : Sun-damaged skin is a relevant target tissue for studying the development of skin cancer. The aim of the present study was to investigate the epidermal response to ultraviolet radiation (UVR) in human skin in vivo and in vitro and to explore the mutagenic effect of UVA. LÄS MER

5. 29. Receptor tyrosine kinase c-Kit signalling in hematopoietic progenitor cells

   Författare :Charlotte Edling; Bengt Hallberg; Pontus Aspenström; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RTK; c-Kit; MAPK; PI3K; PKC; hematopoietic cells; proliferation; differentiation; apoptosis; Pathology; Patologi;

   Sammanfattning : The receptor tyrosine kinase (RTK) c-Kit is expressed in hematopoietic stem and progenitor cells, mast cells and in several non-hematopoietic tissues. In the hematopoietic system c-Kit and its ligand Steel Factor (SF, aka Stem Cell Factor) are critical for proliferation, survival and differentiation. LÄS MER

7. 30. Mast cells in Hodgkin lymphoma : or 'What's a nice cell like you doing in a tumour like this?'

   Författare :Marie Fischer; Gunnar Nilsson; Gunilla Enblad; Tor Olofsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Hodgkin lymphoma; mast cells; CD30; CD30L; IL-9; CCL5; atopic dermatitis; psoriasis; IL-8; Patologi; Pathology; Patologi;

   Sammanfattning : Mast cell (MC) accumulation around tumours is an old observation gaining new relevance due to the multifaceted nature of MCs and their many roles in immunity, beyond allergy. Knowledge about tumour specific recruitment of, and interactions with, MCs is needed to unravel the function of their presence. LÄS MER