Sökning: "Wnt3a"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet Wnt3a.

  1. 1. Studies on the biological functions of interaction between components in Wnt, TGF-β and HIF pathways for cancer progression

    Författare :Karthik Aripaka; Maréne Landström; Jonas von Hofsten; Carl-Henrik Heldin; Ruth Palmer; Lars-Gunnar Larsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TRAF6; HIF-1α; HIF-2α; HIF-3α; ALK5; Wnt3a; Hypoxic signalling; TGF-β; zebrafish; β-Catenin; Pathology; patologi; Oncology; onkologi;

    Sammanfattning : Cancer is a disease that involves aggressive changes in the genome and aberrant signals between the living cells. Signalling pathways such as TGF-β (Transforming growth factor-β), Wnt, EGF (epidermal growth factor) and HIF (Hypoxia-inducible factor) evolved to regulate growth and development in mammals. LÄS MER

  3. 2. Making neurons from stem cells : molecular mechanisms and spider silk substrates

    Författare :Michalina Lewicka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The understanding of the function of the nervous system and the brain is one of the major intellectual challenges in life sciences. Neurological and psychiatric disorders are in addition major issues for the society, and new approaches are needed to learn more about the brain and to develop new treatments. LÄS MER

  4. 3. Wnts in development : focus on midbrain

    Författare :Emma Rakel Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Studies in the field of embryonic development reveal the temporal and spatial requirement of specific genes/proteins in the formation of a given tissue. The specific knowledge of which genes/proteins regulate development of the ventral midbrain (VM) provides a guideline for the in vitro differentiation of specific cell types therein, such as dopaminergic (DA) neurons. LÄS MER

  5. 4. From stem cells to neurons : a BMPy ride

    Författare :Therese Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pinpointing the mechanisms behind the formation of the vertebrate development has been an intriguing and challenging task for researchers for several decades. In the 1980s two independent groups managed to isolate cells from the inner cell mass of a mouse blastocyst and to culture and expand them in vitro, while maintaining their pluripotency. LÄS MER

  7. 5. Regulation of postnatal neurogenesis and brain angiogenesis by thyroid hormone

    Författare :Jenny Liqun Zhang; Göteborgs universitet; []
    Nyckelord :thyroid hormone; neurogenesis; angiogenesis; SVZ OB; hippocampus; neural stem cells; endothelial cells; astrocytes;

    Sammanfattning : Thyroid hormone (TH), which is secreted by the thyroid gland, exerts significant effects on the central nervous system (CNS), especially during development, so that delayed treatment of perinatal hypothyroidism results in severe cognitive retardation. Continuous postnatal neurogenesis occurs throughout adulthood in the subventricular zone (SVZ) of the lateral ventricle wall and in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampal formation. LÄS MER