Sökning: "molecular markers"

Visar resultat 16 - 20 av 611 avhandlingar innehållade orden molecular markers.

1. 16. In Vitro Drug Sensitivity and Apoptosis in Chronic Lymphocytic Leukemia

   Författare :Maria Norberg; Richard Rosenquist; Anna Åleskog; Elin Lindhagen; Gerard Tobin; Per-Ola Andersson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukemia; in vitro drug sensitivity; apoptosis; prognostic markers; Clinical genetics; Klinisk genetik; Haematology; Hematologi; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; MEDICINE; MEDICIN; Medical genetics; Medicinsk genetik; Medical Science; Medicinsk vetenskap; Clinical Genetics; Klinisk genetik; Molekylär genetik; Molecular Genetics; Medical Genetics; Medicinsk genetik; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy displaying varying clinical outcome, where molecular markers today can divide patients into prognostic subgroups. Despite the introduction of new agents for treatment, remissions are usually not sustained in CLL and resistance towards treatment can partly be explained by aberrant apoptosis. LÄS MER

3. 17. RNA-based Prognostic Markers in Chronic Lymphocytic Leukemia

   Författare :Marie Sevov; Richard Rosenquist; Mahmoud Mansouri; Denis Alexander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic lymphocytic leukemia; prognostic markers; RNA-based markers; LPL; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Haematology; Hematologi; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Chronic lymphocytic leukemia (CLL) is a heterogeneous disease where a significant proportion of patients will develop an aggressive disease. Today, the mutational status of the immunoglobulin heavy variable (IGHV) genes is one of the strongest prognostic markers in CLL, where unmutated IGHV genes correlate with poor outcome. LÄS MER

4. 18. Prognostic molecular markers of childhood leukemia

   Författare :Fredrika Gauffin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Acute lymphoblastic leukemia; dic 9; 20 ; dried blood spots; Guthrie card; RNA; PTEN; SHP1; VEGF; VEGFR-1; VEGFR-2; immuhistochemistry; tissue micro array;

   Sammanfattning : During the last decades there has been a dramatic increase in survival rates for childhood leukemia, resulting today in an overall survival close to 90 % for children with acute lymphoblastic leukemia (ALL). This accomplishment is largely due to treatment protocols based on careful risk group assessment guiding the type and intensity of the anti-leukemic treatment. LÄS MER

5. 19. The use of molecular markers for identifying species diversity and functional variation of ectomycorrhizal fungi

   Författare :Jenny Hedh; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ectomycorrhiza; molecular markers; Paxillus involutus; ITS region; phylogenetic species; host compatibility; gene expression; CGH;

   Sammanfattning : Ectomycorrhiza (EM) is a symbiosis between soil living fungi and the roots of woody plants. EM fungal communities are important in forest nutrient cycling, they are species rich and their structures vary between habitats and over time. LÄS MER

7. 20. Padlock Probe-Based Assays for Molecular Diagnostics

   Författare :Anja Mezger; Mats Nilsson; Paul Blainey; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Padlock probes; rolling circle amplification; molecular diagnostics; in situ mutation detection; Biochemistry; biokemi;

   Sammanfattning : Treatment success often depends on the availability of accurate and reliable diagnostic assays to guide clinical practitioners in their treatment choices. An optimal test must excel in specificity and sensitivity, and depending on the application area time, low-cost and simplicity are equally important. LÄS MER