Sökning: "miniaturization"

Visar resultat 6 - 10 av 107 avhandlingar innehållade ordet miniaturization.

1. 6. On chip integrated sample preparation for proteomics

   Författare :Simon Ekström; Avdelningen för Biomedicinsk teknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Elektroteknik; Electrical engineering; enzymologi; Proteiner; enzymology; Proteins; Analytisk kemi; sample preparation; mass spectrometry; microfluidics; miniaturization; Biochemical technology; proteomics; Analytical chemistry; Biokemisk teknik;

   Sammanfattning : The aim of this thesis project has been to create miniaturized analytical tools that improve sample preparation for the very rapidly growing field of proteomics research. The presented miniaturized analytical tools provide novel and generic analytical solutions, which are highly adaptable for analysis of various low abundant biomolecules. LÄS MER

3. 7. Microwell devices for single-cell analyses

   Författare :Sara Lindström; Helene Andersson-Svahn; Mehmet Toner; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; microwell; miniaturization; microfluidics; cell culture; single-cell; clone; imaging; stem cell; cancer; low volume; high-throughput; Molecular biology; Molekylärbiologi;

   Sammanfattning : Powerful tools for detailed cellular studies are emerging, increasing the knowledge ofthe ultimate target of all drugs: the living cell. Today, cells are commonly analyzed inensembles, i.e. thousands of cells per sample, yielding results on the average responseof the cells. LÄS MER

4. 8. Evaluation of a Miniaturized Rotating Disk Apparatus for In Vitro Dissolution Rate Measurements in Aqueous Media : Correlation of In Vitro Dissolution Rate with Apparent Solubility

   Författare :Anita M. Persson; Curt Pettersson; Anders Sokolowski; Anders Karlsson; Alex Avdeef; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; analytical methods; HPLC high-performance liquid chromatography ; miniaturization; in vitro dissolution rate; apparent solubility; physicochemical properties; dissolution media; correlation study; chemometrics; Pharmaceutical chemistry; Farmaceutisk kemi; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Sammanfattning : The general aim of this thesis was to evaluate a newly designed and constructed miniaturized rotating disk apparatus for in vitro dissolution rate measurements of different drug substances from all of the classes in the Biopharmaceutical Classification System (BCS). The new equipment is based on a low volume flow-through cell of Plexiglas, a gold plated magnetic bar and a special designed press. LÄS MER

5. 9. Design and development of electrochemical sensors with application in bioanalysis

   Författare :Kinga Zor; Bioteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; bioanalysis; electrochemistry; sensor; biosensor; miniaturization; real sample; immunoassay; μTAS;

   Sammanfattning : There is a continuous search for reliable, robust, easy to use, portable and cost effective analytical tools with applications in food industry, biomedicine, environmental monitoring and homeland security. The main focus of this thesis is the development of electrochemical (bio)sensors and bioanalysis systems (to be applied in two major fields of interest: food & beverage industry and biomedical research) for monitoring key analytes in complex matrices, such as: meat samples, fermentation broths, and cell culture media. LÄS MER

7. 10. Tailoring of Antibody Arrays - Technical Advances Towards Global Proteome Analysis

   Författare :Linn Petersson; Institutionen för immunteknologi; []
   Nyckelord :antibody arrays; recombinant antibodies; scFv; miniaturization of arrays; immobilization of scFv; global proteome analysis; biomarker discovery;

   Sammanfattning : Abstract The number of cancer and autoimmune disease diagnoses increases in our society, which place high demands on the health care system. Being able to tailor treatments for each individual patient is called "Personalized medicine", and could revolutionize the care in the future. LÄS MER