Sökning: "intracellular assembly"

Visar resultat 1 - 5 av 54 avhandlingar innehållade orden intracellular assembly.

1. 1. Intracellular processing of pre-a-inhibitor

   Författare :Maria Thuveson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; pre-alpha-inhibitor; heavy chain 3; bikunin; intracellular processing; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

   Sammanfattning : Pre-α-inhibitor (PαI) is a plasma protein consisting of a 25 and a 75 kDa polypeptide: bikunin and heavy chain 3 (H3), respectively. Both these polypeptides are made by hepatocytes and while passing through the Golgi complex, bikunin, which carries a chondroitin sulfate chain, becomes covalently linked to the C-terminal amino acid residue of H3 via its polysaccharide. LÄS MER

3. 2. The Francisella pathogenicity island : its role in type VI secretion and intracellular infection

   Författare :Lena Meyer; Anders Sjöstedt; Siobhan C. Cowley; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella; FPI; Type VI Secretion; Igl; DotU; VgrG; Pdp; microinjection; phagosomal escape; intracellular replication; Clinical Bacteriology; klinisk bakteriologi;

   Sammanfattning : Intracellular bacteria have developed various mechanisms to enter and persist in host cells and, at the same time, to evade the host immune response. One such pathogen is Francisella tularensis, the etiological agent of tularemia. LÄS MER

4. 3. Structural and functional studies of C4b-binding protein (C4BP)

   Författare :Lena Kask; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phagocytosis; apoptosis; protein S; complement control protein CCP domains; factor H fH ; Complement; C4b-binding protein C4BP ; intracellular assembly; Clinical chemistry; Klinisk kemi;

   Sammanfattning : The subject of this thesis is complement inhibitor C4b-binding protein (C4BP), on which we have performed both structural and functional studies. Complement is part of the innate immune defence and eliminates microbes, solubilises immune complexes and is involved in the clearance of apoptotic cells. LÄS MER

5. 4. Protein interactions involved in alphavirus assembly

   Författare :Ulrica Skoging Nyberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alphavirus; Semliki Forest Virus; Virus assembly; Capsid Protein; Nucleocapsid; Viral Envelope Proteins;

   Sammanfattning : Viruses have to protect their genomes during transport from the infected to an uninfected host cell. This is achieved by forming a protein shell around the nucleic acid. Virus assembly is a complex process that involves interactions with the viral genome, the viral structural proteins and for enveloped viruses a lipid membrane. LÄS MER

7. 5. Filament assembly and structural studies of intermediate filament like protein, FilP, in Streptomyces coelicolor

   Författare :Ala Javadi; Linda Sandblad; Martin Thanbichler; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytoskeleton; Intermediate filament-like; FilP; Streptomyces coelicolor; filament assembly; cryoelectron tomography; single particle analysis; crystallography; cellulose affinity;

   Sammanfattning : The cytoskeleton, known as intracellular connected filaments, has a prominent role in cellular behavior, motility, and stability. The following three major types of polymers have been characterized as cytoskeleton in eukaryotes: microtubules that are 25 nm in diameter, actin filaments that are 7 nm in diameter, and intermediate filaments (IF) that are 10 nm in diameter. LÄS MER