Sökning: "Type VI Secretion"
Visar resultat 1 - 5 av 53 avhandlingar innehållade orden Type VI Secretion.
1. The Francisella pathogenicity island : its role in type VI secretion and intracellular infection
Sammanfattning : Intracellular bacteria have developed various mechanisms to enter and persist in host cells and, at the same time, to evade the host immune response. One such pathogen is Francisella tularensis, the etiological agent of tularemia. LÄS MER
2. Mechanisms of defective insulin secretion in type 2 diabetes
Sammanfattning : Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. LÄS MER
3. New aspects of voltage-gated calcium channel regulation in pancreatic beta-cells - Relevance for insulin release and type 2 diabetes
Sammanfattning : Voltage-gated Ca2+ channels are essential transducers of cellular signals in many electrically excitable cells. In the pancreatic beta-cell they mediate controlled Ca2+ influx, which is the final trigger for Ca2+ dependent release (exocytosis) of the blood glucose lowering hormone insulin. LÄS MER
4. Small Molecules as Tools in Biological Chemistry : Effects of Synthetic and Natural Products on the Type III Secretion System
Sammanfattning : The increasing use of antibiotics has led to a huge problem for society, as some bacteria have developed resistance towards many of the antibiotics currently available. To help find solutions to this problem we studied small molecules that inhibit bacterial virulence, the ability to cause disease. LÄS MER
5. Pathogenesis of type 2 diabetes -role of defects in insulin secretion and insulin sensitivity
Sammanfattning : Type 2 diabetes is characterised by defects in insulin sensitivity, insulin secretion and increased endogenous glucose production. The relative contribution of each of these defects remains controversial. LÄS MER