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1. 1. GB virus C/hepatitis G virus infection: clinical, histological and epidemiological aspects

   Författare :Per Björkman; Enheten för infektionssjukdomar; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endoscopy; nosocomial; sexual transmission; parenteral transmission; blood donor; ALT; liver disease; hepatitis; GBV-C HGV; HCV; Infections; Infektioner;

   Sammanfattning : GBV-C/HGV is a blood-borne virus related to the hepatitis C virus. We studied GBV-C/HGV infection in different populations, its transmission, and its association with liver disease. GBV-C/HGV viraemia was detected by PCR in 19/576 blood donors. Donors with normal and elevated ALT levels had similar rates of viraemia (1. LÄS MER

3. 2. Hepatitis B virus infection and genomic changes from a long-term perspective

   Författare :Jonas Bläckberg; Sektion III; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; cor promoter; precore; occult infection; HBV; mutation;

   Sammanfattning : Hepatitis B virus is a non-cytopathic virus with a small, circular, partially double-stranded DNA of 3.2 kb. It causes acute and chronic inflammatory liver disease and hepatocellular carcinoma (HCC). Retesting of stored sera from an outbreak of acute hepatitis in 1969-72 allowed identification of 126 cases of acute hepatitis B. LÄS MER

4. 3. Polyomavirus infections in humans

   Författare :Annika Lundstig; Malmö Klinisk mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Polyomaviruses; tumour virology; BK virus; neuroblastoma; maternal infection; Real Time PCR; enzyme immunoassay; seroprevalence; JC virus; SV40; virus like particles VLPs ; seroepidemiology; biobank; mesothelioma tissues; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

   Sammanfattning : The human polyomaviruses BKV and JCV are endemic and infect > 70% of population worldwide. Primary infections occur during childhood and are largely subclinical. Following primary infection, both viruses persist as latent infections in the kidneys and B lymphocytes. LÄS MER

5. 4. Imported infections’ importance : global change driving Dengue dynamics

   Författare :Mikkel B. Quam; Joacim Rocklöv; Annelies Wilder-Smith; Eduardo Massad; Dave D. Chadee; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dengue; Zika; Vector-borne Disease; Aedes; Global Change; Climate Change; Viral Evolution; Phylogenetics; Travel; Interconnectivity; Disease Modeling; Madeira; Italy; Japan; Europe;

   Sammanfattning : Background Dengue is a significant problem of international health concern. According to the World Health Organization in 2012, globally, dengue is “the most important mosquito borne viral disease” with incidence 30 higher than it had been 50 years ago. LÄS MER

7. 5. Role of extracellular ATP in immune mechanisms against infections

   Författare :Lalitha Tadala; Andrea Puhar; Sara I Wilson; Bernt Eric Uhlin; Mikael Sellin; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extracellular ATP; invasive bacteria; Shigella; Listeria; plasma membrane ruffle; PIEZO1; infection; immune response; Hanta virus; molekylär cellbiologi; molecular cell biology;

   Sammanfattning : Inflammation is driven either by infection with pathogens or sterile stimuli, such as tissue damage or autoimmune diseases. Upon tissue damage, ATP is released passively from the dead or compromised cells. During stress, ATP can be secreted from the cells. Extracellular ATP (eATP) acts as an endogenous danger signal. LÄS MER