Sökning: "Bernt Eric Uhlin"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Bernt Eric Uhlin.

  1. 1. Studies of pore-forming bacterial protein toxins in Escherichia coli

    Författare :Constance Enow; Bernt Eric Uhlin; Sun Nyunt Wai; Mikael Rehn; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molekylärbiologi; Molecular Biology;

    Sammanfattning : Escherichia coli, a Gram-negative bacterium, which can be classified into three groups: the commensal, intestinal pathogenic (IPEC) and extra-intestinal pathogenic (ExPEC) E. coli. The cytolysin A (ClyA) protein, a 34-kDa pore-forming toxin, encoded by a gene found in both non-pathogenic and pathogenic E. LÄS MER

  3. 2. Post-transcriptional regulation by RNases in Streptococcus pyogenes

    Författare :Anne-Laure Lécrivain; Emmanuelle Charpentier; Bernt Eric Uhlin; Tracy Nissan; Ciarán Condon; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Post-transcriptional regulation; mRNA decay; RNA sequencing; RNase Y; RNase III; YhaM; PNPase; RNase R; RNase J1; Streptococcus pyogenes.; molekylärbiologi; Molecular Biology;

    Sammanfattning : Ribonucleases (RNases) are proteins that adjust cellular RNA levels by processing RNA transcripts, leading to their stabilization or degradation. RNases are grouped based on their ability to cleave the transcript internally (endoRNases) or degrade the transcript starting from the ends (exoRNases). LÄS MER

  4. 3. Molecular analysis of transcription factors in uropathogenic E. coli adhesin operons

    Författare :Stina Lindberg; Bernt Eric Uhlin; Åsa Sjöling; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; UPEC; E. coli; F1C; P fimbriae; cross-talk; FocB; PapB; crystal structure; OMVs; Medical microbiology; Medicinsk mikrobiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The main causative agent of human urinary tract infections is the uropathogenic Escherichia coli (UPEC) pathotype. It may cause disease due to its ability to express a number of bacterial virulence factors. Fimbrial adhesins are particularly important for the initial establishment of infection in the urinary tract. LÄS MER

  5. 4. Regulatory roles of sRNAs in pathogenesis of Vibrio cholerae

    Författare :Dharmesh Sabharwal; Sun Nyunt Wai; Bernt Eric Uhlin; Jörgen Johansson; Cynthia Sharma; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; sRNA; Biofilm; OmpT; RbmC; Vrp; VafA; mikrobiologi; Microbiology;

    Sammanfattning : The Gram-negative pathogen Vibrio cholerae uses variety of regulatory molecules to modulate expression of virulence factors. One important regulatory element of microorganisms is small non-coding RNAs (sRNAs), which control various cell functions such as expression of cell membrane proteins, mRNA decay and riboswitches. LÄS MER

  7. 5. Pathogenecity-associated genes modulate Escherichia coli adhesion and motility

    Författare :Annika E. Sjöström; Bernt Eric Uhlin; Ann-Beth Jonsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Escherichia coli strains typical of UPEC (uropathogenic E. coli) and NBM (newborn meningitis) isolates carry chromosomally located PAIs (pathogenicity islands) that are absent in non-pathogenic E. coli strains. The PAIs include genes for virulence factors such as toxins and genes coding for specific adhesins and pili/fimbriae formation. LÄS MER