Sökning: "immune escape"

Visar resultat 31 - 35 av 105 avhandlingar innehållade orden immune escape.

  1. 31. Analysis and manipulation of autoreactive and tumor-specific T cell responses

    Författare :Jelena Petrovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Autoimmune Diabetes Mellitus; T cell immune response; proteasome inhibitor;

    Sammanfattning : The focus of this work has been on the analysis and manipulation of T cell responses. One emphasis has been on T cells involved in autoimmune diabetes and another on T cells in tumor immunity. Primary activation of T cells as well as the role of the proteasome in T cell responses has been overlapping themes. LÄS MER

  3. 32. Molecular and cellular strategies to enhance efficacy of T cell-based cancer therapy

    Författare :Pascal Dammeyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :β2-microglobulin; MHC class I antigen defects; immune escape; heal-inducible; amplifier vector; GM-CSF; tumor immunity; T lymphocytes;

    Sammanfattning : A combined approach of vaccination with β2-microglobulin (β2m)-deficient dendritic cells (DCs) and granulocyte-macrophage colony-stimulating factor (GM-CSF) as a potent adjuvant may link cellular and molecular strategies to further enhance anti-tumor T-cell responses. T lymphocytes can mediate a potent anti-tumor immune response. LÄS MER

  4. 33. Modulation of tumor sensitivity to effector mechanisms of cytotoxic lymphocytes

    Författare :Kristian Hallermalm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor escape; cytotoxic lymphocytes; interferon-gamma; TNF-alpha; granzyme B; Perforin; Fas ligand;

    Sammanfattning : Today, ample evidence demonstrates a clear role for the immune system in the battle against cancer. However, the relatively high rate of mutation and proliferation of tumor cells, in combination with the selective pressure exerted by the immune system, can potentially lead to the generation of genetically altered tumor cells, which are able to evade recognition by the immune system and continue to grow and form tumors. LÄS MER

  5. 34. Novel approaches for cancer immunotherapy

    Författare :Fredrik Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer immunotherapy, i.e. activation of the patient s own immune system to combat cancer, represents a treatment strategy which is being clinically tested to complement surgery, radiotherapy and chemotherapy the current cornerstones of our fight against cancer. LÄS MER

  7. 35. Immunogene Therapy of Bladder Carcinoma : A Preclinical Study

    Författare :Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Immunotherapy; Gene therapy; Immunogene therapy; CD40L; Bladder carcinoma; Onkologi; Oncology; Onkologi; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : This thesis comprises studies on murine and human models of bladder carcinoma with the aim to develop novel immunogene therapies. On the basis of the results presented in this thesis, a clinical trial is underway. The potential of activating the immune system to combat cancer has long intrigued immunologists. LÄS MER