Sökning: "immune escape"

Visar resultat 21 - 25 av 105 avhandlingar innehållade orden immune escape.

  1. 21. HIV-1 immune responses induced by natural infection or immunisation

    Författare :Lindvi Gudmundsdotter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The development of an effective HIV-1 vaccine must be considered as one of today s greatest biomedical goals and challenges. The nature of the HIV-1 virus, characterised by its tropism for the CD4+ T cells of the immune system and its integration into the host genome, together with the vast viral variability, allows the HIV-1 virus to establish a latent infection and evade the host defence mechanisms. LÄS MER

  3. 22. Mapping the immune landscape in solid tumors : implications for immunotherapy

    Författare :Emelie Foord; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our cells are programmed with various safety mechanisms to avoid transformation into tumor cells. In case these fail, we have a guarding immune system ready to recognize and eliminate these cells. Despite these safety measurements, cancer is one of the leading causes of death worldwide. The tumor cells find ways to escape the immune system. LÄS MER

  4. 23. The Francisella pathogenicity island : its role in type VI secretion and intracellular infection

    Författare :Lena Meyer; Anders Sjöstedt; Siobhan C. Cowley; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella; FPI; Type VI Secretion; Igl; DotU; VgrG; Pdp; microinjection; phagosomal escape; intracellular replication; Clinical Bacteriology; klinisk bakteriologi;

    Sammanfattning : Intracellular bacteria have developed various mechanisms to enter and persist in host cells and, at the same time, to evade the host immune response. One such pathogen is Francisella tularensis, the etiological agent of tularemia. LÄS MER

  5. 24. The transcriptomic landscape of Epstein-Barr virus associated tumors at cellular and single-molecule level

    Författare :Yarong Tian; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; carcinogenesis; RPMS1; miRNA; single-cell sequencing; immune evasion;

    Sammanfattning : Epstein-Barr virus (EBV) was the first oncovirus found in humans. Almost all adults worldwide are asymptomatic carriers of EBV. The latent EBV-infection malignifies in approximately 200,000 individuals each year. LÄS MER

  7. 25. Host-Pathogen Interactions in Pseudomonas aeruginosa Invasive and Respiratory Tract Infection

    Författare :Magnus Paulsson; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pseudomonas aeruginosa; vitronectin; Respiratory tract infections; Innate Immunity; outer membrane vesicles; outer membrane proteins; beta-lactamase; ciprofloxacin; combination treatment; bacteraemia; Complement escape;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic bacterium that causes debilitating infections when the immune defence is compromised. It possesses an arsenal of virulence traits to colonize most compartments of the body and is often highly resistant against commonly used antimicrobial drugs. LÄS MER