Sökning: "Pascal Dammeyer"

Hittade 2 avhandlingar innehållade orden Pascal Dammeyer.

1. 1. Cancer vaccine strategies and studies of human thioredoxin reductase splice variants

   Författare :Pascal Dammeyer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cancer involves abnormal, uncontrolled proliferation of cells, and evasion from the immune system. Immune evasion can be caused by defects in one or more of the components of the major histocompatibility complex class I antigen machinery, e.g. the beta2-microglobulin (beta2m) molecule. LÄS MER

3. 2. Molecular and cellular strategies to enhance efficacy of T cell-based cancer therapy

   Författare :Pascal Dammeyer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :β2-microglobulin; MHC class I antigen defects; immune escape; heal-inducible; amplifier vector; GM-CSF; tumor immunity; T lymphocytes;

   Sammanfattning : A combined approach of vaccination with β2-microglobulin (β2m)-deficient dendritic cells (DCs) and granulocyte-macrophage colony-stimulating factor (GM-CSF) as a potent adjuvant may link cellular and molecular strategies to further enhance anti-tumor T-cell responses. T lymphocytes can mediate a potent anti-tumor immune response. LÄS MER