Sökning: "proteasome inhibitor"
Visar resultat 1 - 5 av 49 avhandlingar innehållade orden proteasome inhibitor.
1. Investigating the activation and regulation of the proteasome : an essential proteolytic complex
Sammanfattning : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. LÄS MER
2. Identification and characterization of a proteasome deubiquitinase inhibitor
Sammanfattning : The 26S proteasome has emerged as an attractive therapeutic target in the treatment of cancers. Proteasome inhibitors have been shown to selectively kill cancer cells. The FDA approval of bortezomib for the treatment of multiple myeloma and mantle cell lymphoma has clinically validated the 26S proteasome as a therapeutic target in oncology. LÄS MER
3. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes
Sammanfattning : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. LÄS MER
4. Studies of b-AP15 : a novel inhibitor of proteasome deubiquitinase activity
Sammanfattning : Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful in treatment of multiple myeloma patients but acquired resistance and adverse side-effect highly decreased patients’ quality of life. Development of 2nd generation proteasome inhibitors that could overcome these shortcomings is thus of prime medical importance. LÄS MER
5. The ubiquitin-proteasome system during proteotoxic stress
Sammanfattning : The dual function of the ubiquitin-proteasome system in protein quality control and as a master regulator of vital cellular processes places the system in a delicate position. This might be particularly relevant under patho-physiological conditions such as endoplasmic reticulum stress, which provoke the accumulation of aberrant proteins. LÄS MER
