Sökning: "histone modifications"

Visar resultat 16 - 20 av 77 avhandlingar innehållade orden histone modifications.

1. 16. The Nucleosome as a Signal Carrying Unit : From Experimental Data to Combinatorial Models of Transcriptional Control

   Författare :Stefan Enroth; Jan Komorowski; Claes Wadelius; Rickard Sandberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Next generation sequencing; Nucleosome; Histone modification; Transcriptional regulation; Bioinformatics; Bioinformatik; Bioinformatics; Bioinformatik; Bioinformatik; Bioinformatics;

   Sammanfattning : The human genome consists of over 3 billion nucleotides and would be around 2 meters long if uncoiled and laid out. Each human somatic cell contains all this in their nucleus which is only around 5 µm across. This extreme compaction is largely achieved by wrapping the DNA around a histone octamer, the nucleosome. LÄS MER

3. 17. Gene regulation during development by chromatin and the Super Elongation Complex

   Författare :Olle Dahlberg; Mattias Mannervik; Peter Gergen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila development; gene regulation; transcription; chromatin; P-TEFb; Super Elongation Complex; KDM4A; H3K36me3; H3K14ac; histone replacement; utvecklingsbiologi; Developmental Biology;

   Sammanfattning : Developmental processes are carefully controlled at the level of transcription to ensure that the fertilized egg develops into an adult organism. The mechanisms that controls transcription of protein-coding genes ultimately ensure that the Pol II machine synthesizes mRNA from the correct set of genes in every cell type. LÄS MER

4. 18. Epigenetic regulation of gene expression in the vascular endothelium

   Författare :Mia Magnusson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epigenetics; histone acetylation; DNA methylation; t-PA; PLAT; HUVECs; valproic acid; gene expression; enhancers;

   Sammanfattning : Epigenetic mechanisms, such as DNA methylation and histone modifications, constitute one way for a cell or an organism to respond to changes in the surrounding environment. While histone modifications are recognized to be quite dynamic, DNA methylation has been considered a more stable, or long-term, modification. LÄS MER

5. 19. A Bioinformatics Study of Human Transcriptional Regulation

   Författare :Adam Ameur; Jan Komorowski; Claes Wadelius; Philipp Bucher; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; microarray; ChIP-chip; ChIP-seq; transcription factor; histone modification; motif search; Bioinformatics; Bioinformatik;

   Sammanfattning : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. LÄS MER

7. 20. Regulation of differentiation during the Giardia life cycle : An insight into the molecular control

   Författare :Laura Rojas-López; Staffan Svärd; Marco Lalle; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Giardia; cell differentiation; encystation; histone post-translational modifications; host-parasite interaction;

   Sammanfattning : Giardia intestinalis (syn. G. lamblia, G. duodenalis) is an intestinal protozoan parasite that causes diarrheal infections worldwide. LÄS MER