Sökning: "histone modifications"

Visar resultat 21 - 25 av 77 avhandlingar innehållade orden histone modifications.

1. 21. On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate

   Författare :Karolina Wallenborg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Development of an organism requires correct spatial and temporal regulation of gene expression. Epigenetic regulation of gene expression has been shown to be an important part of many cellular events. Nucleosomes consist of two subunits of each core histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. LÄS MER

3. 22. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells

   Författare :Veronika Viktorija Borutinskaite; Karl Eric Magnusson; Ruta Navakauskiene; Tor Olofsson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; leukemia; histone deacetylase inhibitors; retinoic acid; differentiation; apoptosis; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. LÄS MER

4. 23. Modulating chromatin by transcription and nucleosome turnover : a genome-wide study in fission yeast

   Författare :Laia Sadeghi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Eukaryotic DNA is wrapped around histone proteins to form a nucleosome, the basic structural unit of chromatin. Multiple levels of chromatin organization are required to compact DNA into chromosomes, to ensure an accurate cell division. LÄS MER

5. 24. The CHD chromatin remodeling factors in schizosaccharomyces pombe

   Författare :Julian Walfridsson; Karl Ekwall; Pernilla Bjerling; Stefan Björklund; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Regulation of chromatin structure is essential in a wide variety of processes including transcriptional regulation, recombination, replication, chromosome segregation, development and differentiation. The enzymes that are central in regulating chromatin structure can be classified into two major groups. LÄS MER

7. 25. Human Adipocytes : Proteomic Approaches

   Författare :Åsa Jufvas; Peter Strålfors; Alexander Vener; Maria V Turkina; Hans Jörnvall; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Type 2 diabetes is characterized by increased levels of glucose in the blood originating from insulin resistance in insulin sensitive tissues and from reduced pancreatic insulin production. Around 400 million people in the world are diagnosed with type 2 diabetes and the correlation with obesity is strong. LÄS MER