Sökning: "enhancers"

Visar resultat 1 - 5 av 74 avhandlingar innehållade ordet enhancers.

  1. 1. Epigenetic regulation of gene expression in the vascular endothelium

    Författare :Mia Magnusson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epigenetics; histone acetylation; DNA methylation; t-PA; PLAT; HUVECs; valproic acid; gene expression; enhancers;

    Sammanfattning : Epigenetic mechanisms, such as DNA methylation and histone modifications, constitute one way for a cell or an organism to respond to changes in the surrounding environment. While histone modifications are recognized to be quite dynamic, DNA methylation has been considered a more stable, or long-term, modification. LÄS MER

  3. 2. Oral delivery of macromolecules formulated with permeation enhancers

    Författare :Staffan Berg; Christel Bergström; Nigel Davies; Andreas Hugerth; David Brayden; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral peptide delivery; permeation enhancer; sodium caprate; oral drug delivery; intestinal absorption of macromolecules; Biofarmaci; Biopharmaceutics; Galenisk farmaci; Pharmaceutics;

    Sammanfattning : Therapeutic macromolecules including peptides, proteins, and nucleotide-based ones (such as antisense oligonucleotides and RNAs) have great potential as drug candidates. One drawback is that they typically need to be administered parenterally via subcutaneous, intramuscular or intravenous injections. LÄS MER

  4. 3. Plantaricins as a novel group of antibacterial compounds and enhancers of antibiotics

    Författare :Amani Musa; Hazem Khalaf; Torbjörn Bengtsson; Elena Vikström; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bacteriocin; antimicrobial peptide; plantaricin; antibiotic resistance; PLNC8 αβ; ESKAPE pathogens;

    Sammanfattning : Antibiotics have revolutionized medicine, however, the rapid development of an-tibiotic resistance among bacteria is diminishing their efficacy. Antimicrobial pep-tides produced by Lactobacillus plantarum, i.e., plantaricins, are considered prom-ising alternatives to antibiotics against infections. LÄS MER

  5. 4. Astrocytes in glioblastoma : enhancers of tumor growth, predictors of patient survival and potential therapeutic targets

    Författare :Alessandro Mega; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor microenvironment plays an important role in glioblastoma, the most malignant primary brain tumor in adults. Astrocytes are a major component of the glioblastoma tumor microenvironment; therefore, their influence on glioblastoma biology needs to be clarified. LÄS MER

  7. 5. Mucin-like fusion proteins produced in Pichia pastoris as enhancers of immunogenecity of recombinant vaccines

    Författare :Magnus Sjöblom; Sven-Olof Enfors; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biokemisk processteknik; Biochemical Process Engineering;

    Sammanfattning : .... LÄS MER