Sökning: "halogen bonding"
Visar resultat 1 - 5 av 13 avhandlingar innehållade orden halogen bonding.
1. Characterising Halogen Bonding in a Cooperative Model System
Sammanfattning : Non-covalent interactions are the main driving factor for secondary structure formation of biomacromolecules and are of enormous importance for the direction of molecular recognition events, for example those of importance for drug discovery. Profound understanding of these interactions is of vital importance to achieve high affinity and selectivity of a ligand to a chosen target. LÄS MER
2. Reactivity of late transition metal complexes towards CO2 and other electrophiles
Sammanfattning : In times when dwindling energy resources is a major long-term problem for sustaining modern infrastructure and technologies, we need to focus on more enduring solutions. A key contribution to this achievement is catalysis. LÄS MER
3. The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development
Sammanfattning : Understanding the solution conformation and dynamics of molecules with biological relevance, as well as the impact of their conformation stabilizing weak interactions, is for example important for drug design. Macrocycles have attractive pharmaceutical properties, and are of special interest as drug leads for targets with large, flat and featureless binding sites like protein-protein interfaces. LÄS MER
4. Investigation of [N-X-N]+ and [N-C-N]+ complexes in solution : Exploring Geometry, Stability and Symmetry
Sammanfattning : Halogen bonding is a weak interaction. In this thesis the three center four electron halogen bond, [N−X−N]+, has been studied. The lighter halogens form highly unstable halonium ions that are reactive towards nucleophiles and their complexes were therefore investigated at low temperatures. LÄS MER
5. Design, Synthesis and Thermodynamic Studies of Galectin Ligands
Sammanfattning : The signaling within and between cells in biology is governed by molecular recognition between natural or synthetic ligands and proteins. This thesis project aimed to investigate the thermodynamic properties of specific interaction between synthetic ligands and galectin proteins. LÄS MER