Sökning: "solution conformational analysis"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden solution conformational analysis.

  1. 1. Metallocene based peptidomimetics and chiral catalysts

    Detta är en avhandling från Organic Chemistry, Lund University

    Författare :Suzana Maricic; Lunds universitet.; Lund University.; [2002]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; asymmetric catalysis.; metallocene based amino alcohols; one-pot macrocyclisation; cyclic peptides; Organometallic substance P and Leu 5 -enkephalin; conformational analysis;

    Sammanfattning : Popular Abstract in Swedish Ett antal optiskt aktiva metalloorganiska Phe-AAn-Phe subenheter har syntetiserats via intramolekulär cyklisering av motsvarande bis(aminosyra)derivat. Bis(aminosyra)derivaten var i sin tur erhållna från en förbättrad multistegssyntes, vars nyckelsteg är Horner-Wadswort-Emmons olefinering av metalloorganiska aldehyder med fosfonylglycin-reagens, enantioselektiv hydrogenering av didehydroaminosyror och klassisk lösnings- och/eller fastfas peptid syntetisk metodologi. LÄS MER

  2. 2. Modulation of Molecular Properties Host–Guest Interactions for Structural Analysis and Chemical Reactions

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Norrehed; Uppsala universitet.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; host-guest systems; conformational analysis; NMR spectroscopy; bispidines; porphyrins; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Sammanfattning : This thesis concerns the construction, use and modulation of various host–guest systems, from small bispidines for binding of inorganic ions to bisporphyrin clips for supramolecular systems.Small flexible molecules undergo fast conformational movements when in solution. LÄS MER

  3. 3. Synthesis, conformational analysis, and biological evaluation of peptides from E. coli P pilus proteins

    Detta är en avhandling från Organic Chemistry, Lund University

    Författare :Katarina Flemmer Karlsson; Lunds universitet.; Lund University.; [1997]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; CD spectroscopy; peptide structure; ELISA; solid-phase peptide synthesis; peptide; P pili; chaperone; Organic chemistry; Organisk kemi;

    Sammanfattning : Many bacteria utilize hairlike protein appendages (pili) to attach themselves to mucosal cell surfaces in the host organism. The pilus is assembled from protein subunits synthesized inside the bacteria and transported to the outer cell wall for incorporation into the growing pilus. LÄS MER

  4. 4. The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development

    Detta är en avhandling från Göteborgs universitet

    Författare :Emma Danelius; Göteborgs universitet.; Gothenburg University.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Macrocycles; cyclic peptides; NMR; solution conformational analysis; NAMFIS; β-hairpin; weak interactions; halogen bonding; protein-protein interaction; bioactive conformation; macrolides; cell permeable conformation.;

    Sammanfattning : Understanding the solution conformation and dynamics of molecules with biological relevance, as well as the impact of their conformation stabilizing weak interactions, is for example important for drug design. Macrocycles have attractive pharmaceutical properties, and are of special interest as drug leads for targets with large, flat and featureless binding sites like protein-protein interfaces. LÄS MER

  5. 5. NMR spectroscopy in structural and conformational analysis of bacterial polysaccharides

    Detta är en avhandling från Stockholm : Department of Organic Chemistry, Stockholm University

    Författare :Carolina Fontana; Stockholms universitet.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear Magnetic Resonance; carbohydrates; O-antigen polysaccharide; Organic Chemistry; organisk kemi;

    Sammanfattning : Carbohydrates constitute one of the three major classes of biomolecules found in all living cells and, unlike nucleic acids and proteins, their polymeric structures are not based on a template. The structural diversity of these molecules confers them an enormous capacity to encode information in biological systems, acting as efficient mediators in the interaction of the cell with the environment. LÄS MER