Sökning: "diastereomer"
Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet diastereomer.
1. Design, Synthesis and Thermodynamic Studies of Galectin Ligands
Sammanfattning : The signaling within and between cells in biology is governed by molecular recognition between natural or synthetic ligands and proteins. This thesis project aimed to investigate the thermodynamic properties of specific interaction between synthetic ligands and galectin proteins. LÄS MER
2. Chemo-enzymatic cascades for the synthesis of chiral high-value chemicals
Sammanfattning : Chiral amines are frequent in today´s top selling pharmaceuticals. Classical organic synthesis of pharmaceuticals is often work intensive involving many synthesis steps, the use of protection group chemistry, heavy metal catalysts and chiral crystallization techniques. LÄS MER
3. Flexibility – a tool for chirality control in asymmetric catalysis
Sammanfattning : This thesis deals with the design and synthesis of ligands for asymmetric catalysis: palladium catalyzed allylic alkylations, and rho-dium and iridium catalyzed hydrogenations of olefins. Chirally flexible phosphepine ligands based on biphenyl were synthesized and their properties were studied. LÄS MER
4. Engineered Yeast as Biocatalyst for Stereoselective reductions of Dicarbonyl Compounds
Sammanfattning : Chiral building blocks are needed in the chemical and pharmaceutical industries for the production of fine chemicals and pharmaceuticals. The utilisation of microorganisms and enzymes to perform stereoselective reductions of carbonyl compounds is an efficient and widely applied method for the generation of chiral molecules. LÄS MER
5. Asymmetric [2,3]-Sigmatropic Rearrangement of Allylic Ammonium Ylides
Sammanfattning : The thesis describes the realization of an asymmetric [2,3]-sigmatropic rearrangement of achiral allylic amines. It is divided into two parts; the first part deals with the development of a Lewis acid-mediated [2,3]-sigmatropic rearrangement and the second the asymmetric version thereof. LÄS MER