Sökning: "genetic disease models"
Visar resultat 31 - 35 av 289 avhandlingar innehållade orden genetic disease models.
31. Models for infections in immunodeficiency
Sammanfattning : Increased susceptibility to infections in immunodeficient patients is a well-known phenomenon. The spectrum of infections reflects the underlying defect. Experimental infections in mouse strains with different types of defined immunodeficiencies allow studying the course of infectious diseases in immunocompromised hosts. LÄS MER
32. Mind & Well-being : The relationships between personality and health related pathology
Sammanfattning : The study of the associations between personality, lifestyle and health related pathology has revealed important associations. These include associations with physical health such as the onset of cardiovascular disease, but also with mental and emotional health such as depression or life satisfaction. LÄS MER
33. Genetics of Diabetes Subtypes. Characterization of novel cluster-based diabetes subtypes
Sammanfattning : BACKGROUND: Type 2 diabetes (T2D) has been reproducibly clustered into five subtypes based on six-clinical variables; age at diabetes onset, body mass index (BMI), Glutamic acid decarboxylase autoantibodies (GADA), glycated hemoglobin (HbA1c) and insulin secretion and resistance estimated as HOMA2B and HOMA2IR derived from fasting glucose and Cpeptide. These subtypes have different disease progression and risk of complications. LÄS MER
34. Lifestyle and glycaemic control before and after the onset of type 2 diabetes
Sammanfattning : Type 2 diabetes (T2D) is a complex disease with widespread physiological insults to the regulation of metabolic homeostasis, above all glycaemic regulation. The pathogenesis of T2D and its progression is broadly understood to be through a gradual decrease in peripheral insulin sensitivity, a compensatory rise in insulin secretion, and a gradual decline in beta-cell function, resulting in glycaemic dysregulation and eventual T2D. LÄS MER
35. Genetic and genomic analysis of arthritis regulating regions in human and mouse
Sammanfattning : Identifying genes involved in the disease pathways of complex diseases such as Rheumatoid arthritis (RA) has been shown to be very difficult. Despite decades of research still only a handful of genes have been convincingly identified as risk genes. LÄS MER